中医药调控白癜风相关信号通路研究进展  

Traditional Chinese Medicine Regulates Signaling Pathways to Treat Vitiligo:A Review

作　　者：董晓仪 王绍莹 杨锐[1] 王泽芸 方殿伟 李奕辰 王远红[3] DONG Xiaoyi;WANG Shaoying;YANG Rui;WANG Zeyun;FANG Dianwei;LI Yichen;WANG Yuanhong(Heilongjiang University of Chinese Medicine,Harbin 150040,China;Shenzhen Hospital,University of Chinese Academy of Sciences,Shenzhen 518106,China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]中国科学院大学深圳医院,广东深圳518106 [3]黑龙江中医药大学附属第一医院,哈尔滨150040

出　　处：《中国实验方剂学杂志》2023年第24期233-240,共8页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金面上项目(81873312);黑龙江省自然科学基金项目(LH2022H077,H201462);哈尔滨市科技创新人才研究专项(2016RAXYJ102)。

摘　　要：白癜风是一种皮肤基底层黑素细胞损害缺失引起的皮肤着色障碍性皮肤病,表现为头面部、毛发、乳晕、生殖器、黏膜和创伤部位边界分明的象牙白色、乳白色色素岛,严重影响患者的正常社交及身心健康。该病作为一种患病率逐年攀升的损美性疑难皮肤病已引起医学界的广泛重视。目前已提出的自身免疫、黑素细胞自噬、氧化应激、自体细胞毒性、神经体液、遗传和环境因素等发病假说仍存在研究盲点。西医临床常用的糖皮质激素、小分子拮抗剂、钙调神经磷酸酶抑制剂、生物制剂、维生素D衍生物、光疗、手术治疗等方法存在不良反应大、易复发等缺陷。中医药调控白癜风以其治疗通路广、作用靶点全、简验廉效且不良反应小等优势给广大医患带来福音,多项研究显示中药单体及复方可通过调控该病多条信号通路促进黑素细胞自噬,保护黑素细胞免受氧化应激进而促使白斑复色。但目前中医药调控白癜风相关信号通路的系统总结较少,故该综述通过检索近几年国内外相关文献资料,介绍中医药调控白癜风的主要信号通路[即分子氢激活核因子E_(2)相关因子2(Nrf2)通路、酪氨酸激酶受体(c-Kit)信号转导通路、核转录因子-κB(NF-κB)信号通路、Janus酪氨酸蛋白激酶(JAK)信号通路、丝裂原活化蛋白激酶(MAPK)信号通路、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)信号通路、腺苷酸活化蛋白激酶(AMPK)通路]以飨同道。Vitiligo,a skin pigmentation disorder caused by the loss of melanocytes in the basal layer of the skin,is manifested as creamy white or ivory white pigmented islands on the head,face,hair,areola,genitals,mucous membranes and traumatic areas with distinct borders,seriously affecting the patient’s social,physical,and mental health.The disease has attracted wide attention in the medical circle as a difficult aesthetic dermatosis with an increasing prevalence year by year.There are still blind spots in the hypotheses that autoimmunity,melanocyte autophagy,oxidative stress,autocytotoxicity,neurohumors,and genetic and environmental factors are associated with the pathogenesis of this disease.The commonly used Western medical therapies,including glucocorticoids,small-molecule antagonists,calcium-regulated neurophosphatase inhibitors,biologics,vitamin D derivatives,phototherapy,and surgery are flawed with side effects and prone to recurrence.Traditional Chinese Medicine(TCM)can treat vitiligo via a wide range of pathways and targets,with definite effects and low adverse reactions.Studies have demonstrated that TCM can promote autophagy of melanocytes and protect them from oxidative stress.However,there are few systematic summaries of the signaling pathways in the TCM treatment of vitiligo.Therefore,this paper introduces the main signaling pathways involved in the TCM treatment of vitiligo by reviewing the relevant articles published at home and abroad in recent years.Specifically,the signaling pathways include the molecular hydrogen-activated nuclear factor erythroid-related factor 2(Nrf2),tyrosine kinase receptor(c-Kit),nuclear transcription factor-κB(NF-κB),Janus tyrosine protein kinase(JAK),mitogen-activated protein kinase(MAPK),phosphatidylinositol 3-kinase(PI3K)/protein kinase B(Akt),and adenosine monophosphate-activated protein kinase(AMPK)signaling pathways.

关 键 词：中医药 白癜风 信号通路 作用机制 研究进展 

分 类 号：R2-031[医药卫生—中西医结合] R932[医药卫生—中医学] R256.35R758.41