金果榄化学成分、药理作用研究进展  

Advances in Chemical Constituents and Pharmacological Action of Tinosporae Radix

作　　者：王晶晶 杨汝薇 谢永艳 徐子薇 王帅康 陈丽苹 蓝道远 郭秋锦 黄丽萍[1,3] WANG Jingjing;YANG Ruwei;XIE Yongyan;XU Ziwei;WANG Shuaikang;CHEN Liping;LAN Daoyuan;GUO Qiujin;HUANG Liping(School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China;The Third Xiangya Hospital of Central South University,Changsha 410013,China;Jiangxi Provincial Key Laboratory of Pharmacology of Traditional Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学药学院,南昌330004 [2]中南大学湘雅三医院,长沙410013 [3]江西省中药药理重点实验室,南昌330004

出　　处：《中国实验方剂学杂志》2023年第24期273-282,共10页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江西中医药大学校级科技创新团队项目(CXTD22007);国家自然科学基金项目(82060759,81660713);江西省研究生创新专项(YC2022-s839);江西中医药大学创新创业项目(202310412014);江西中医药大学国家中医药管理局中医药重点学科培育学科项目。

摘　　要：中药材金果榄为防己科青牛胆属植物青牛胆(Tinospora sagittata)或金果榄(T.capillipes)的干燥块根。首载于清代的《本草纲目拾遗》,是我国的传统中药材,在历版《中华人民共和国药典》中有收载,秋、冬二季采挖,除去须根,洗净,晒干后用,主治咽喉肿痛、痈疽疔毒、腰腹疼痛及各种热证,常用于治疗慢性炎症,药效显著有“壮药中的广谱抗菌素”之称,是广西壮族、瑶族习用中药材,具有广泛的应用开发价值和研究意义。现代研究表明,金果榄所含的成分主要有二萜、生物碱、甾醇、蒽醌、糖苷、脂肪酸和挥发油等类化合物,具有抗炎镇痛、抗菌抑菌、抗氧化、抗糖尿病、抗肿瘤抗癌等众多药理活性,在抑炎、治疗咽喉肿痛等疾病方面取得良好的疗效。近年来有较多关于金果榄资源状况、化学成分、药理作用、临床应用、质量评价等方面研究报道,但目前尚无较为系统的综述介绍,该文通过查阅文献资料并结合现代研究,对金果榄做较为系统性归纳整理,以期为金果榄资源的综合开发利用和后续的深入研究提供指导。Tinosporae Radix,as a traditional Chinese medicinal herb,is the dried root tuber of Tinospora sagittata or T.capillipes.It was first recorded in the Compendium of Materia Medica Supplement in the Qing Dynasty and included in the previous edition of the Chinese Pharmacopoeia.Tinosporae Radix is excavated in autumn and winter and used after removing fibrous roots,washing,and drying.It is indicated for sore throat,carbuncle boils poison,waist and abdominal pain,and various heat syndromes and is commonly used to treat chronic inflammation.Its efficacy is significantly known as“broad-spectrum antibiotics in Zhuang medicine”.Tinosporae Radix is a traditional Chinese medicinal herb often taken by Zhuang and Yao nationalities in Guangxi province and has a wide range of application and development values and research significance.Modern studies have shown that Tinosporae Radix contains diterpenoids,alkaloids,sterols,anthraquinones,glycosides,fatty acids,volatile oils,and other compounds,which have many pharmacological activities such as anti-inflammatory and analgesic,antibacterial and antibacterial,antioxidant,anti-diabetic,and anti-tumor and anti-cancer effects,and it has achieved good efficacy in inhibiting inflammation and treating sore throat and other diseases.In recent years,there have been many research reports on the status,chemical constituents,pharmacological action,clinical application,and quality evaluation of Tinosporae Radix resources,but there is no systematic review and introduction at present.By consulting the literature and combining it with modern research,this paper systematically summarizes and collates Tinosporae Radix resources to provide guidance for the comprehensive development and utilization of Tinosporae Radix resources and subsequent in-depth study.

关 键 词：金果榄 名称考证 萜类 生物碱 抗炎 

分 类 号：R284.2[医药卫生—中药学] R285[医药卫生—中医学] R289R287R22R2-031R33R24