脓毒症继发急性肠胃损伤血清TFF3和CRP水平及其预测价值  

Serum TFF3 and CRP of sepsis patients with secondary acute gastrointestinal injury and predictive values

作　　者：何莉莉 潘朝 吴丽娟[1] 陈分乔[1] 陈领然 刘艳君 HE Li-li;PAN Zhao;WU Li-juan;CHEN Fen-qiao;CHEN Ling-ran;LIU Yan-jun(Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang,Hebei 050000,China;不详)

机构地区：[1]河北省中医院急诊科,河北石家庄050000 [2]河北以岭医院神经内科,河北石家庄050000 [3]河北省中医院感控公卫处,河北石家庄050000

出　　处：《中华医院感染学杂志》2023年第21期3257-3260,共4页Chinese Journal of Nosocomiology

基　　金：河北省自然科学基金资助项目(H2022423369);河北省中医药管理局基金资助项目(2021075,2021091)。

摘　　要：目的研究脓毒症继发急性肠胃损伤血清肠三叶因子(TFF3)和C-反应蛋白(CRP)水平及其预测价值.方法选取2020年8月-2022年8月河北省中医院急诊科接诊的60例脓毒症患者为研究对象,其中继发急性肠胃损伤患者34例为研究组,未继发急性肠胃损伤患者26例为对照组.收集患者一般资料,比较两组血清TFF3、CRP水平,继发急性肠胃损伤危险因素以及危险因素对继发急性肠胃损伤的预测作用.结果研究组患者序贯器官衰竭(SOFA)评分以及急性生理学及慢性健康状况评分(APACHE)Ⅱ高于对照组(P<0.05).研究组TFF3、CRP水平高出对照组(P<0.05).Logistic回归分析结果可见,APACHEⅡ评分、TFF3为患者继发急性肠胃损伤的危险因素.血清TFF3水平对脓毒症患者继发急性肠胃损伤的预测效果高于APACHEⅡ评分指标(P<0.05).结论脓毒症继发急性肠胃损伤患者血清检测TFF3和CRP指标明显增高,且TFF3检测能够作为患者继发急性肠胃损伤的一些早期预测标志物.OBJECTIVE To explore the levels of serum intestinal trefoil factor(TFF3)and C-reaetive protein(CRP)in sepsis patients with secondary acute gastrointestinal injury and analyze the predictive values.METHODS A toual of 60 patients with sepsis who were treated in emergency department of Hebei Provineial Hospital of Tra-ditional Chinese Medicine from Aug 2020 to Aug 2022 were recruited as the research subjects.34 of whom had secondary acute gastrointestinal injury and were assigned as the study group,26 who did not have secondary acute gastrointestinal injury and were assigned as the control group.The baseline data were ollcted from the patients,the levels of serum TFF3 and CRP were compared between the two groups,the risk factors for the secondary acute gastrointestinal injury and the values of the risk factors in prediction of secondary acute gastrointestinal injury were observed.RESULTS The scores of sequential organ failure assessment(SOFA)and acute physiology and chronic health evaluation(APACHE)I of the study group were higher than those of the control group(P<0.05).The levels of TFF3 and CRP of the study group were higher than those of the control group(P<0.05).The result of logistic regression analysis showed that APACHEⅡscore and TFF3 were the risk factors for the secondary acute gastrointestinal injury.The efect of the serum TFF3 was higher than that of the APACHEⅡscore on prediction of the secondary acute gastrointestinal injury in the patients with sepsis(P<0.05).CONCLUSION The sepsis patients with secondary acute gastrointestinal injury show remarkable rise of serum TFF3 and CRP.and TFF3 can be used as a marker for prediction of the secondary acute gastrointestinal injury.

关 键 词：肠三叶因子 C-反应蛋白 脓毒症 急性肠胃损伤 危险因素 

分 类 号：R631[医药卫生—外科学]