2012-2022年某综合医院门诊男性患者人乳头瘤病毒感染状况和基因型分布  

Prevalence and genotypes of human papillomavirus infection among male outpatient department patients of a general hospital from 2012 to 2022

作　　者：李丰田[1] 田颖新 童红莉[1] 陈聪哲 李名 赵靳鑫 王钰 张樱[1] LI Feng-tian;TIAN Ying-xin;TONG Hong-li;CHEN Cong-zhe;LI Ming;ZHAO Jin-xin;WANG Yu;ZHANG Ying(The First Medical Center of PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心检验科,北京100853

出　　处：《中华医院感染学杂志》2023年第22期3447-3451,共5页Chinese Journal of Nosocomiology

基　　金：北京市科学自然基金资助项目(6222033)。

摘　　要：目的分析某综合医院门诊男性患者人乳头瘤病毒感染状况和基因型分布.方法收集2012年1月-2022年12月解放军总医院第一医学中心门诊送检的5078例男性首次就诊标本,采用荧光定量聚合酶链式反应(PCR)方法对HPV进行检测,分析其亚型分布及感染特征.结果受检男性患者共检出HPV阳性1737例,总体阳性率34.21%.按亚型频次分布,低危型HPV6/11是最常见的感染亚型,占53.83%,其次是高危型以HPV16、52、51、58为主,分别占13.59%、10.02%、9.15%和8.35%;按感染状态分析,单纯高危型感染占比45.60%,高低危混合型感染占比20.26%;单一感染1198例,占68.97%;多重感染539例,占31.03%;多重感染中,二重、三重、四重感染的感染率较高,分别为21.13%、6.10%和2.53%,且多重感染中的高低危混合型占比均高于单纯低危型和单纯高危型(P<0.05);按年龄分布,>20~30岁感染阳性率最高,达38.57%.就诊患者疾病呈现多样化,尖锐湿疣和泌尿系感染位居前两位,占比51.01%和13.47%.结论11年间HPV总体感染率整体呈下降趋势,单纯低危型感染率呈下降趋势,但高危型感染率整体呈上升趋势.为预防HPV感染,应重视男性HPV检测和治疗意识,推荐男性接种HPV疫苗.OBJECTIVE To investigate the prevalence and genotypes of human papillomavirus infection among the male outpatient department patients of a general hospital.METHODS The specimens were collected from 5078 male patients who were initially treated in outpatient department of the First Medical Center of PLA General Hospital from Jan 2012 to Dec 2022.HPV test was carried out by florescent quantitative polymerase chain reaction(PCR),and the subtypes and characteristics of the infection were observed.RESULTS Totally 1737 cases were tested positive for HPV among the enrolled male patients,with the total positive rate 34.21%.In terms of the subtypes,the low-risk type HPV6/11(53.83%)was the most common subtype,followed by the high-risk subtypes HPV16(13.59%),HPV52(10.02%),HPV51(9.15%)and HPV58(8.35%).In terms of infection status,the patients with simple high-risk infection accounted for 45.60%,the patients with mixed high and low risk infection accounted for 20.26%.There were 1198(68.97%)cases of simple infection and 539(31.03%)cases of multiple infections.Among the patients with the multiple infections,the patients with double infections accounted for 21.13%,the patients with triple infections 6.10%,the patients with quadruple infections 2.53%.Among the patients with multiple infection,the proportion of the patients with mixed high and low-risk infections was higher than that of the patients with simple low-risk infection and the patients with simple high-risk infection(P<0.05).In terms of age,the positive rate was highest(38.57%)among the patients aged between 20 and 30 years old.The patients presented with diversified diseases,condyloma acuminata and urinary system infection ranked the top 2,accounting for 51.01%and 13.47%,respectively.CONCLUSION The overall incidence rate of HPV infection shows a downward trend in the ll years,the incidence of simple low-risk infection shows a downward trend,but the incidence of high-risk infection shows an upward trend.It is necessary to attach great importance to the HPV test and trea

关 键 词：人乳头瘤病毒 男性 高危型 低危型 尖锐湿疣 人乳头瘤病毒疫苗 

分 类 号：R752[医药卫生—皮肤病学与性病学]