盆腔炎病原学及血清HMGB1、IL-2、MCP-1对其诊断价值  

Etiological characteristics and values of serum HMGB1,IL-2 and MCP-1 in diagnosis of pelvic inflammatory disease

作　　者：陈颖 夏劲[2] 魏春清 汪艳[3] 周易[4] CHEN Ying;XIA Jin;WEI Chun-qing;WANG Yan;ZHOU Yi(Huanggang Central Hospital,Huanggang,Hubei 438000,China)

机构地区：[1]黄冈市中心医院妇产科,湖北黄冈438000 [2]黄冈市中心医院麻醉科,湖北黄冈438000 [3]黄冈市中心医院医院感染管理科,湖北黄冈438000 [4]黄冈市中心医院药剂科,湖北黄冈438000

出　　处：《中华医院感染学杂志》2023年第22期3466-3470,共5页Chinese Journal of Nosocomiology

基　　金：湖北省科研基金资助项目(2022HG03021)。

摘　　要：目的探讨盆腔炎病原学及血清高迁移率族蛋白B1(HMGB1)、白细胞介素-2(IL-2)、单核细胞趋化蛋白(MCP-1)对其诊断价值.方法选取2020年3月-2022年12月黄冈市中心医院收治的盆腔炎患者102例为病例组,并根据盆腔炎感染程度分为轻度组28例、中度组44例和重度组30例,另随机选取110名健康体检者为对照组.比较各组沙眼衣原体、解脲支原体、淋球菌及血清HMGB1、IL-2、MCP-1水平,统计解脲支原体药敏试验结果,并分析血清HMGB1、IL-2、MCP-1对盆腔炎的诊断价值.结果病例组沙眼衣原体、解脲支原体、淋球菌感染率高于对照组;重度组高于中度组和轻度组,且中度组高于对照组(P<0.05).病例组血清HMGB1、MCP-1水平高于对照组;重度组高于中度组和轻度组,且中度组高于对照组(P<0.05);病例组血清IL-2水平低于对照组;重度组低于中度组和轻度组,且中度组低于对照组(P<0.05).102例盆腔炎患者对环丙沙星、左氧氟沙星耐药率较高.血清HMGB1、IL-2、MCP-1诊断盆腔炎曲线下面积(AUC)分别为0.897、0.937、0.928,三者比较无统计学差异.结论沙眼衣原体、解脲支原体、淋球菌与盆腔炎发病及感染程度有关,且解脲支原体对环丙沙星、左氧氟沙星的耐药性较高,另血清HMGB1、MCP-1在盆腔炎患者中呈高表达,血清IL-2中呈低表达,三者与盆腔炎感染程度有关,且三者对盆腔炎的诊断价值均较高.OBJECTIVE To explore the etiological characteristics of the patients with pelvic inflammatory disease and analyze the diagnostic values of serum high-mobility group protein B1(HMGB1),interleukin-2(IL-2)and monocyte chemotactic protein 1(MCP-1).METHODS A total of 102 patients with pelvic inflammatory disease who were treated in Huanggang Central Hospital from Mar 2020 to Dec 2022 were assigned as the case group and were divided into the mild group with 28 cases,the moderate group with 44 cases and the severe group with 30 cases according to the severity of pelvic inflammation.llo healthy people who received physical examination were chosen as the control group.The Chlamydia trachomatis,Mycoplasma urealytium and Gonococci as well as the levels of serum HMGB1,IL-2 and MCP-1 were compared among the groups,the result of drug susceptibility testing for the M.urealytium was statistically analyzed,and the values of serum HMGB1,IL-2 and MCP-1 in diagnosis of pelvic inflammatory diseases were analyzed.RESULTS The incidence rates of C.trachomatis,M.urealytium and Gonococci infections of the case group were higher than those of the control group,the incidence rates of the infections of the severe group were higher than those of the moderate group and the mild group,and the incidence rates of the infections of the moderate group were higher than those of the control group(P<o.05).The levels of serum HMGBl and MCP-1 of the case group were higher than those of the control group,the levels of the indexes of the severe group were higher than those of the moderate group and the mild group,and the levels of the above indexes of the moderate group were higher than those of the control group(P<0.05).The serum IL-2 level of the case group was lower than that of the control group,the serum IL-2 level of the severe group was lower than that of the moderate group and the mild group,and the serum IL-2 level of the moderate group was lower than that of the control group(P<0.05).The 102 patients with pelvic inflammatory diseases were highly

关 键 词：盆腔炎 病原体 沙眼衣原体 解脲支原体 淋球菌 耐药性 高迁移率族蛋白B1 白细胞介素-2 单核细胞趋化蛋白 诊断价值 

分 类 号：R711.33[医药卫生—妇产科学]