上消化道恶性肿瘤患者围手术期使用含ω-3多不饱和脂肪酸制剂的有效性和安全性meta分析  

Meta-analysis of the efficacy and safety for ω-3 polyunsaturated fatty acid of patients with upper gastrointestinal cancer during the perioperative period

作　　者：孙辉 王海银[1] 何达[1] 覃肖潇 刘昕 顾一纯 金春林[1] SUN Hui;WANG Haiyin;HE Da;QIN Xiaoxiao;LIU Xin;GU Yichun;JIN Chunlin(Shanghai Health Development Research Center(Shanghai Medical Information Center),Shanghai 201199,China)

机构地区：[1]上海市卫生和健康发展研究中心(上海市医学科学技术情报研究所),上海201199

出　　处：《世界临床药物》2023年第10期1075-1083,共9页World Clinical Drug

摘　　要：目的系统评价上消化道恶性肿瘤患者围手术期使用含ω-3多不饱和脂肪酸制剂或标准肠内营养制剂的有效性和安全性,为临床合理用药提供参考。方法计算机检索Pubmed、EMbase、The Cochrane Library、中国知网及万方医学等数据库,搜集相关文献。检索时限均从建库至2022年6月1日。由2位研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,应用Stata16.0软件进行meta分析。结果共纳入38篇随机对照研究。Meta结果显示,含有ω-3多不饱和脂肪酸的肠内营养制剂与标准肠内营养制剂相比,在降低消化道肿瘤患者感染并发症(相对危险度=0.75,P<0.001)、改善免疫和炎症相关指标、白蛋白以及减少住院天数(加权均数差=-2.321,P<0.05)等方面显示出了更好的优势。结论含有ω-3多不饱和脂肪酸的肠内营养制剂在上消化道肿瘤术后营养治疗中有效性和安全性方面具有优势,可以作为临床优选用药。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。Objective To systematically evaluate the efficacy and safety of enteral nutrition preparations containingω-3 polyunsaturated fatty acids or standard enteral nutrition preparations in patients with upper gastrointestinal cancer during the perioperative period,and to provide reference for clinical rational drug use.Methods Pubmed,EMbase,the Cochrane Library,CNKI,and Wanfang databases were searched for relevant literature.The search time limit was from the establishment of the database to June 1,2022.Two researchers independently screened the literature,extracted data and assessed the risk of bias of the included studies.Stata16.0 software was used for meta-analysis.Results A total of 38 randomized controlled trials were included.The results of meta-analysis showed that compared with the standard enteral nutrition,enteral nutrition preparations containingω-3 polyunsaturated fatty acids were more effective in reducing the infectious complications(relative risk=0.75,P<0.001),improving immune and inflammation-related indicators,albumin,and reducing the length of hospital stay(weighted mean differenc=-2.321,P<0.05).Conclusion Enteral nutrition preparations containingω-3 polyunsaturated fatty acids have advantages in efficacy and safety in postoperative nutritional therapy for upper gastrointestinal cancer,and can be used as the preferred clinical drug.Limited by the quantity and quality of the included studies,the above conclusions need to be verified by more high-quality studies.

关 键 词：上消化道肿瘤 Ω-3多不饱和脂肪酸 META分析 

分 类 号：R977.6[医药卫生—药品]