钴催化氘代甲氧基化苯甲酰胺衍生物的合成研究  

Cobalt-catalyzed Deuteromethylation of Benzamide Derivatives

作　　者：王梦萍 Wang Mengping(College of Chemistry and Chemical Engineering,Hubei University,Wuhan 430062,China)

机构地区：[1]湖北大学化学化工学院,湖北武汉430062

出　　处：《山东化工》2023年第18期48-52,共5页Shandong Chemical Industry

摘　　要：由于C-D键独特的稳定性和标记作用,在化合物中引入氘对于候选药物的合成以及反应机理的研究具有重要意义。芳基醚是一种在药物、溶剂和聚合物前体等方面具有应用前景与价值的化合物,广泛存在于药物中间体和农业生产中。本文根据C-D键和芳基醚类化合物的双重优势,以氘代甲醇为氘源,开发了一种钴(II)/水杨醛配体组成的催化体系,在氧化条件下高效合成了氘代甲氧基化芳烃化合物,该方法无需使用酸碱添加剂,反应条件温和,具有良好的官能团相容性和氘掺入量,各种不同取代的苯甲酰胺衍生物产率中等至良好。Due to the unique stability and labeling effect of the C-D bond,the introduction of deuterium into compounds is of great significance for the synthesis of candidate drugs and the study of reaction mechanisms.Aryl ethers are compounds with potential applications and value in pharmaceuticals,solvents,and polymer precursors,and Widely present in pharmaceutical intermediates and agricultural production.Based on the dual advantages of C-D bonds and aryl ethers,a system consisting of cobalt/salicylaldehyde ligands has been developed using deuterated methanol as a deuterium source to efficiently synthesize deuterated methoxylated aromatic compounds under oxidative conditions.This method does not require the use of acid base additives,and the reaction conditions are mild,with good functional group compatibility and deuterium incorporation,The yield of various substituted benzamide derivatives is medium to good.

关 键 词：钴催化 氘代甲氧基化 苯甲酰胺 水杨醛配体 

分 类 号：O625.11[理学—有机化学]