单核铟配合物的合成和抗肿瘤活性研究  

Synthesis and Antitumor Activity of Mononuclear Indium Complex

作　　者：盖爽爽 蓝峻峰 甘庆蓝 蒋才云 Gai Shuangshuang;Lan Junfeng;Gan Qinglan;Jiang Caiyun(School of Food and Biochemical Engineering,Guangxi Science&Technology Normal University,Laibin 545004,China)

机构地区：[1]广西科技师范学院食品与生化工程学院,广西来宾545004

出　　处：《山东化工》2023年第18期81-83,87,共4页Shandong Chemical Industry

基　　金：广西高校中青年教师科研基础能力提升项目(2019KY0853,2020KY23016);广西科技师范学院自然科学基金项目(GXKS2023ZDA001,GXKS2023ZDA003)。

摘　　要：以2-噻唑甲醛和氨基硫脲合成的配体,再与氯化铟合成了一个铟配合物(配合物1),采用X-射线单晶衍射仪解析了其结构。通过MTT法测试了配合物1对不同的癌细胞株(MGC-803、SKOV3和HepG2)的细胞毒性,发现其对人肝癌细胞株HepG2活性最优。通过线粒体膜电位和细胞凋亡等实验结果表明配合物1能够诱导HepG2细胞线粒体功能障碍并抑制细胞内ATP的生成,最终诱导癌细胞凋亡。Indium complex(complex 1)was synthesized from 2-thiazole-formaldehyde and thiosemicarbazide ligand with indium chloride,and its structure was analyzed by X-ray single crystal diffrotometer.The cytotoxicity of complex 1 against different cancer cell lines(MGC-803,SKOV3 and HepG2)was tested by MTT assay,and complex 1 had the best activity against human hepatoma cell line HepG2.Mitochondrial membrane potential,apoptosis and other experiments showed that complex 1 could induce mitochondrial dysfunction,inhibit intracellular ATP production in HepG2 cells,and induce cancer cells apoptosis.

关 键 词：铟配合物 抗肿瘤活性 线粒体膜电位 

分 类 号：O614.821[理学—无机化学]