小儿低温等离子射频消融术麻醉过程中应用亚临床剂量艾司氯胺酮的效果分析  

Analysis of the Effect of Sub-clinical Dose of Esketamine Hydrochloride Injection in the Anesthesia Process of Low Temperature Plasma Radiofrequency Ablation in Children

作　　者：李艳青 马向军 任宪凤 LI Yanqing;MA Xiangjun;REN Xianfeng(Anesthesiology Department of Anyang Sixth People’s Hospital,Anyang 455000,Henan,China)

机构地区：[1]安阳市第六人民医院麻醉科,河南安阳455000

出　　处：《中国药物滥用防治杂志》2023年第11期1884-1887,共4页Chinese Journal of Drug Abuse Prevention and Treatment

摘　　要：目的:探讨亚临床剂量艾司氯胺酮在小儿低温等离子射频消融术中对疼痛、血流动力学和手术应激的影响。方法:按照随机数字表法将2021年7月—2022年12月就诊于安阳市第六人民医院的80例鼾症患儿分为对照组与观察组,所有患儿均行低温等离子射频消融术。对照组患儿麻醉诱导采用罗库溴铵注射液+咪达唑仑注射液+枸橼酸舒芬太尼注射液+丙泊酚乳状注射液静脉推注,麻醉维持采用注射用盐酸瑞芬太尼+丙泊酚乳状注射液静脉泵注;观察组患儿麻醉诱导采用罗库溴铵注射液+咪达唑仑注射液+盐酸艾司氯胺酮注射液+丙泊酚乳状注射液静脉推注,麻醉维持采用亚临床剂量盐酸艾司氯胺酮注射液+丙泊酚乳状注射液静脉泵注。比较两组疼痛程度、血流动力学指标及应激反应指标水平。结果:观察组患儿拔管后5 min、15 min、30 min、1 h疼痛程度均低于对照组(P<0.05),而两组患儿拔管时疼痛程度比较,差异无统计学意义(P>0.05)。两组术后心率、平均动脉压及血氧饱和度均低于术前,而观察组高于对照组(P<0.05)。观察组SOD、GSH水平均高于对照组,MDA水平低于对照组(P<0.05)。结论:亚临床剂量艾司氯胺酮在小儿低温等离子射频消融术中麻醉镇痛效果较好,对患儿血流动力学影响较小,可降低患儿术后应激反应,利于患儿预后。Objective:To investigate the effects of sub-clinical dose of esketamine hydrochloride injection on pain,hemodynamics and surgical stress in children undergoing low-temperature plasma radiofrequency ablation.Methods:According to the random number table method,80 children with snoring who were treated in Anyang Sixth People’s Hospital from July 2021 to December 2022 were divided into control group and observation group.All children underwent low-temperature plasma radiofrequency ablation.The control group was given intravenous injection of rocuronium bromide injection+midazolam injection+sufentanil citrate injection+propofol emulsion injection for anesthesia induction,and intravenous pumping of remifentanil hydrochloride injection+propofol emulsion injection for anesthesia maintenance.The observation group was given intravenous injection of rocuronium bromide injection+midazolam injection+esketamine hydrochloride injection+propofol emulsion injection for anesthesia induction,and intravenous pumping of sub-clinical dose of esketamine hydrochloride injection+propofol emulsion injection for anesthesia maintenance.The pain degree,hemodynamic indexes and stress response indexes were compared between the two groups.Results:The degree of pain in the observation group at 5 minutes,15 minutes,30 minutes,and 1 hour after extubation was lower than that in the control group(P<0.05),and there was no statistically significant difference in the degree of pain during extubation between the two groups(P>0.05).The postoperative heart rate,mean arterial pressure,and blood oxygen saturation of both groups were lower than before surgery,while the observation group was higher than the control group(P<0.05).The levels of SOD and GSH in the observation group were higher than those in the control group,while the levels of MDA were lower than those in the control group(P<0.05).Conclusion:Sub-clinical dose of esketamine hydrochloride injection has a good anesthetic and analgesic effect in pediatric low-temperature plasma radiofrequency abl

关 键 词：小儿鼾症 低温等离子射频消融术 亚临床剂量 盐酸艾司氯胺酮注射液 

分 类 号：R726.1[医药卫生—儿科]