有丝分裂原激活的蛋白激酶作用激酶抑制剂研究进展  

Research progress of MNK inhibitors

作　　者：曾扬杰 金鹏耀 曹志豪 李文欣 任晓东 ZENG Yang-jie;JIN Peng-yao;CAO Zhi-hao;LI Wen-xin;REN Xiao-dong(Medical College,Guizhou University,Guiyang 550025,China)

机构地区：[1]贵州大学医学院,贵阳550025

出　　处：《中国新药杂志》2023年第21期2155-2163,共9页Chinese Journal of New Drugs

基　　金：贵州省科技计划资助项目(黔科合基础-ZK[2021]一般556);贵州大学引进人才科研项目(贵大人基合字(2020)76号)。

摘　　要：有丝分裂原激活的蛋白激酶作用激酶(MNK)对真核细胞翻译起始因子4E(eIF4E)209位丝氨酸的磷酸化作用与肿瘤相关mRNA的翻译起始过程密切相关,在肿瘤的发生、转移等过程中具有重要作用,MNK已经逐渐成为抗肿瘤的重要靶标。近年来MNK小分子抑制剂的开发已受到了研究人员的关注,因此本文在总结MNK的结构和信号转导机制的基础上,对MNK小分子抑制剂的研究进展进行综述。The phosphorylation of serine 209 of eukaryotic translation initiation factor 4E(eIF4E)by mitogen-activated protein kinase-interacting kinase(MNK)is closely related to the process of translation initiation of tumor-related mRNA,and this process plays an important role in tumor occurrence and metastasis.Since MNK has gradually become an important antitumor target,the development of MNK small-molecule inhibitors has attracted the attention of researchers in recent years.Therefore,we reviewed the research progress of MNK small-molecule inhibitors by summarizing the structure and signal transduction mechanism of MNK.

关 键 词：有丝分裂原激活的蛋白激酶作用激酶 真核细胞翻译起始因子4E 肿瘤 抑制剂 

分 类 号：R979.1[医药卫生—药品]