Multi-phase separation in mitochondrial nucleoids and eukaryotic nuclei  

作　　者：Qi Long Yanshuang Zhou Jingyi Guo Hao Wu Xingguo Liu 

机构地区：[1]CAS Key Laboratory of Regenerative Biology,Joint School of Life Sciences,The Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People’s Hospital,Guangzhou Medical University,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou 510530,China [2]Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine,China-New Zealand Joint Laboratory on Biomedicine and Health,CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine,Institute for Stem Cell and Regeneration,Institute for Stem Cell and Regeneration,Guangzhou Institutes of Biomedicine and Health,Chinese Academy of Sciences,Guangzhou 510530,China [3]Centre for Regenerative Medicine and Health,Hong Kong Institute of Science&Innovation,Chinese Academy of Sciences,Hong Kong SAR,China

出　　处：《Biophysics Reports》2023年第3期113-119,共7页生物物理学报(英文版)

基　　金：funded by the National Natural Science Foundation projects of China(92157202,32025010,32241002,92254301,32261160376,31970709,32070729,32100619,32170747);the National Key Research and Development Program of China(2022YFA1103800,2019YFA0904500);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0480000);the Key Research Program,CAS(ZDBS-ZRKJZ-TLC003);International Cooperation Program,CAS(154144KYSB20200006);CAS Project for Young Scientists in Basic Research(YSBR-075);Guangdong Province Science and Technology Program(2023A1515030231,2022A1515110493,2020B1212060052,2021A1515012513,2021B1515020096,2022A1515012616,2022A1515110951);Guangzhou Science and Technology Program(202102020827,202102080066);Open research funds of the Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People’s Hospital(202301-203);Open Research Program of Key Laboratory of Regenerative Biology,CAS(KLRB202107,KLRB202203);CAS Youth Innovation Promotion Association(to Y.W and K.C)。

摘　　要：In mammalian cells,besides nuclei,mitochondria are the only semi-autonomous organelles possessing own DNA organized in the form of nucleoids.While eukaryotic nuclear DNA compaction,chromatin compartmentalization and transcription are regulated by phase separation,our recent work proposed a model of mitochondrial nucleoid self-assembly and transcriptional regulation by multi-phase separation.Herein,we summarized the phase separation both in the nucleus and mitochondrial nucleoids,and did a comparison of the organization and activity regulating,which would provide new insight into the understanding of both architecture and genetics of nucleus and mitochondrial nucleoids.

关 键 词：SEPARATION PHASE summarized 

分 类 号：Q244[生物学—细胞生物学]