肠道病毒组在疾病中的治疗潜力及其机制研究进展  

Research progress on potential and mechanism of intestinal virome in treating diseases

作　　者：邱树涛 武树奇 许宁宁[2] 许勇豪 杨锐[2] 王娟 苏符贵 陈容平[2] QIU Shutao;WU Shuqi;XU Ningning;XU Yonghao;YANG Rui;WANG Juan;SU Fugui;CHEN Rongping(Southern Medical University,Guangzhou 510515,Guangdong,China;Department of Endocrinology and Metabolism,Zhujiang Hospital,Southern Medical University,Guangzhou 510280,Guangdong,China;Department of Orthodontics,Stomatological Hospital,Southern Medical University,Guangzhou 510280,Guangdong,China;Suixi People’s Hospital,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524300,Guangdong,China)

机构地区：[1]南方医科大学,广东广州510515 [2]南方医科大学珠江医院内分泌代谢科,广东广州510280 [3]南方医科大学口腔医院正畸科,广东广州510280 [4]广东医科大学附属医院遂溪医院,广东湛江524300

出　　处：《微生物学通报》2023年第11期5172-5189,共18页Microbiology China

摘　　要：肠道病毒组是人体肠道微生态系统中的重要组成部分。近年来,肠道微生态与疾病的关系受到广泛关注,越来越多的证据表明粪菌移植过程中病毒组的转移对粪菌移植的疗效起到了不可忽视的作用。本文根据近些年的相关研究,综述粪菌移植中肠道病毒组在疾病中的治疗潜力,总结肠道病毒组在疾病治疗中的可能机制,同时对肠道病毒组在未来疾病治疗中的应用作出展望。The intestinal virome is an important component of the human intestinal microecosystem.In recent years,the relationship between intestinal microbiome and diseases has attracted extensive attention.More and more evidence has demonstrated that the transfer of intestinal virome in fecal microbiota transplantation is essential for the efficacy of the therapy.By reviewing the relevant studies in recent years,this article summarizes the therapeutic potential and possible mechanisms of intestinal virome in fecal microbiota transplantation,and makes an outlook on the application of intestinal virome in disease treatment.

关 键 词：肠道病毒组 噬菌体 治疗潜力 机制 

分 类 号：R373[医药卫生—病原生物学]