Clinical study of NFNC in the treatment of acute exacerbation chronic obstructive pulmonary disease patients with respiratory failure  

作　　者：Xiang Chen Ling Dai Jin-Zhu Ma Xin-Xu Chu Liang Dai Jian-Ming Liu Si-Wei Guo Xin-Wei Ru Xue-Shi Zhuang 

机构地区：[1]Pulmonary and Critical Care Medicine,The Sixth Hospital of Wuhan,Affiliated Hospital of Jianghan University,Wuhan 430000,Hubei Province,China [2]Department of Intensive Care Second Unit,Wuhan No.1 Hospital,Wuhan 430000,Hubei Province,China [3]Department of Intensive Care Medicine,Lixin County People's Hospital,Bozhou 236700,Anhui Province,China

出　　处：《World Journal of Clinical Cases》2023年第32期7770-7777,共8页世界临床病例杂志

摘　　要：BACKGROUND Most patients with acute exacerbation chronic obstructive pulmonary disease(AECOPD)have respiratory failure that necessitates active correction and the improvement of oxygenation is particularly important during treatment.High flow nasal cannula(HFNC)oxygen therapy is a non-invasive respiratory aid that is widely used in the clinic that improves oxygenation state,reduces dead space ventilation and breathing effort,protects the loss of cilia in the airways,and improves patient comfort.AIM To compare HFNC and non-invasive positive pressure ventilation in the treatment of patients with AECOPD.METHODS Eighty AECOPD patients were included in the study.The patients were in the intensive care department of our hospital from October 2019 to October 2021.The patients were divided into the control and treatment groups according to the different treatment methods with 40 patients in each group.Differences in patient comfort,blood gas analysis and infection indices were analyzed between the two groups.RESULTS After treatment,symptoms including nasal,throat and chest discomfort were significantly lower in the treatment group compared to the control group on the 3rd and 5th days(P<0.05).Before treatment,the PaO_(2),PaO_(2)/FiO_(2),PaCO_(2),and SaO_(2)in the two groups of patients were not significantly different(P>0.05).After treatment,the same indicators were significantly improved in both patient groups but had improved more in the treatment group compared to the control group(P<0.05).After treatment,the white blood cell count,and the levels of C-reactive protein and calcitonin in patients in the treatment group were significantly higher compared to patients in the control group(P<0.05).CONCLUSION HFNC treatment can improve the ventilation of AECOPD patients whilst also improving patient comfort,and reducing complications.HFNC is a clinically valuable technique for the treatment of AECOPD.

关 键 词：Acute exacerbation chronic obstructive pulmonary disease HFNC Noninvasive positive pressure ventilation Application value 

分 类 号：R473.5[医药卫生—护理学]