Interstitial pneumonia combined with nocardia cyriacigeorgica infection:A case report  

作　　者：Dao-Da Qi Yi Zhuang Yang Chen Jing-Jing Guo Ze Zhang Yan Gu 

机构地区：[1]Department of Geriatrics,The Second Hospital of Nanjing,Nanjing University of Chinese Medicine,Nanjing 210003,Jiangsu Province,China [2]Department of Respiratory and Critical Care Medicine,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing 210006,Jiangsu Province,China

出　　处：《World Journal of Clinical Cases》2023年第32期7920-7925,共6页世界临床病例杂志

基　　金：Medical Science and Technology Development Foundation,Nanjing Department of Health,No.YKK20067.

摘　　要：BACKGROUND Nocardia infection is a relatively uncommon disease,with no reports among patients with interstitial pneumonia.Due to its atypical clinical symptoms and chest computed tomography(CT)findings and the frequent yielding of negative results by conventional cultures,it poses challenges for timely diagnosis and treatment.CASE SUMMARY A 63-year-old female patient presented to our hospital in July 2022 with a 3-mo history of intermittent cough and poor appetite,accompanied by a 2-wk long duration of headaches.She had a previous medical history of interstitial pneumonia and was on oral prednisone and cyclosporine.Chest CT revealed the presence of newly developed round nodules.The diagnosis of Nocardia cyriacigeorgica infection was confirmed through metagenomic next-generation sequencing(mNGS)performed on bronchoalveolar lavage fluid.Targeted antiinfection therapy was initiated,resulting in symptom improvement and radiological resolution,further validating the mNGS results.CONCLUSION Nocardia cyriacigeorgica infection is a clinically rare condition that is primarily observed in immunocompromised patients.Its clinical and radiological manifestations lack specificity,but mNGS can aid in rapidly obtaining pathogenic information.Early initiation of targeted antimicrobial therapy based on mNGS results can improve patient prognosis.

关 键 词：Interstitial pneumonia Nocardia cyriacigeorgica infection Literature review Case report 

分 类 号：R563[医药卫生—呼吸系统]