Causal associations between inflammatory bowel disease and anxiety:A bidirectional Mendelian randomization study  

作　　者：Ying He Chun-Lan Chen Jian He Si-De Liu 

机构地区：[1]Department of Gastroenterology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,Guangdong Province,China [2]Department of Infectious Diseases,The Second Xiangya Hospital of Central South University,Changsha 410011,Hunan Province,China [3]Department of Pulmonary and Critical Care Medicine,Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,Guangdong Province,China

出　　处：《World Journal of Gastroenterology》2023年第44期5872-5881,共10页世界胃肠病学杂志（英文版）

基　　金：Supported by China Postdoctoral Science Foundation,No.2021M701614;Guangdong Basic and Applied Basic Research Foundation,No.2022A1515111063,No.2022A1515111045;Foundation of Guangdong Provincial People’s Hospital,No.8200010545。

摘　　要：BACKGROUND Anxiety is common in patients with inflammatory bowel disease(IBD),including those with ulcerative colitis(UC)and Crohn’s disease(CD);however,the causal relationship between IBD and anxiety remains unknown.AIM To investigate the causal relationship between IBD and anxiety by using bidirectional Mendelian randomization analysis.METHODS Single nucleotide polymorphisms retrieved from genome-wide association studies(GWAS)of the European population were identified as genetic instrument variants.GWAS statistics for individuals with UC(6968 patients and 20464 controls;adults)and CD(5956 patients and 14927 controls;adults)were obtained from the International IBD Genetics Consortium.GWAS statistics for individuals with anxiety were obtained from the Psychiatric Genomics Consortium(2565 patients and 14745 controls;adults)and FinnGen project(20992 patients and 197800 controls;adults),respectively.Inverse-variance weighted was applied to assess the causal relationship,and the results were strengthened by heterogeneity,pleiotropy and leave-one-out analyses.RESULTS Genetic susceptibility to UC was associated with an increased risk of anxiety[odds ratio:1.071(95%confidence interval:1.009-1.135),P=0.023],while genetic susceptibility to CD was not associated with anxiety.Genetic susceptibility to anxiety was not associated with UC or CD.No heterogeneity or pleiotropy was observed,and the leave-one-out analysis excluded the potential influence of a particular variant.CONCLUSION This study revealed that genetic susceptibility to UC was significantly associated with anxiety and highlighted the importance of early screening for anxiety in patients with UC.

关 键 词：Inflammatory bowel disease ANXIETY Causal effect Mendelian randomization Genome-wide association studies 

分 类 号：R684[医药卫生—骨科学] R574[医药卫生—外科学]