Metachronous primary esophageal squamous cell carcinoma and duodenal adenocarcinoma:A case report and review of literature  

作　　者：Chun-Chun Huang Le-Qian Ying Yan-Ping Chen Min Ji Lu Zhang Lin Liu 

机构地区：[1]Department of Oncology,Zhongda Hospital,Medical School of Southeast University,Nanjing,Jiangsu Province,210009,China

出　　处：《World Journal of Gastrointestinal Surgery》2023年第11期2627-2638,共12页世界胃肠外科杂志（英文版）（电子版）

摘　　要：BACKGROUND The prevalence of multiple primary malignant neoplasms(MPMNs)is increasing in parallel with the incidence of malignancies,the continual improvement of diagnostic models,and the extended life of patients with tumors,especially those of the digestive system.However,the co-existence of MPMNs and duodenal adenocarcinoma(DA)is rarely reported.In addition,there is a lack of compre-hensive analysis of MPMNs regarding multi-omics and the tumor microenvir-onment(TME).CASE SUMMARY In this article,we report the case of a 56-year-old man who presented with a complaint of chest discomfort and abdominal distension.The patient was diagnosed with metachronous esophageal squamous cell carcinoma and DA in the Department of Oncology.He underwent radical resection and chemotherapy for the esophageal tumor,as well as chemotherapy combined with a programmed death-1 inhibitor for the duodenal tumor.The overall survival was 16.6 mo.Extensive evaluation of the multi-omics and microenvironment features of primary and metastatic tumors was conducted to:(1)Identify the reasons responsible for the poor prognosis and treatment resistance in this case;and(2)Offer novel diagnostic and therapeutic approaches for MPMNs.This case demonstrated that the development of a second malignancy may be independent of the location of the first tumor.Thus,tumor recurrence(including metastases)should be distinguished from the second primary for an accurate diagnosis of MPMNs.CONCLUSION Multi-omics characteristics and the TME may facilitate treatment selection,improve efficacy,and assist in the prediction of prognosis.Core Tip:Multiple primary malignant neoplasms(MPMNs)are increasingly prevalent in clinical practice,most frequently in the digestive system.We report a rare case of MPMN with a combination of esophageal squamous cell carcinoma and duodenal adenocarcinoma.According to PubMed-indexed literature,there are no standard guidelines or expert consensus on the etiology and comprehensive treatment.We also conducted a detailed study of the feature

关 键 词：Multiple primary malignancies Esophageal tumor Duodenal adenocarcinoma Multi-omics Tumor microenvironment Case report 

分 类 号：R523[医药卫生—内科学] R816.5[医药卫生—临床医学]