Cardiovascular implications of inflammatory bowel disease: An updated review  

作　　者：Arshia Bhardwaj Arshdeep Singh Vandana Midha Ajit Sood Gurpreet Singh Wander Bishav Mohan Akash Batta 

机构地区：[1]Department of Gastroenterology,Dayanand Medical College and Hospital,Punjab,Ludhiana 141001,India [2]Department of Internal Medicine,Dayanand Medical College and Hospital,Punjab,Ludhiana 141001,India [3]Department of Cardiology,Dayanand Medical College and Hospital,Punjab,Ludhiana 141001,India

出　　处：《World Journal of Cardiology》2023年第11期553-570,共18页世界心脏病学杂志（英文版）（电子版）

摘　　要：Emerging data highlights the heightened risk of atherosclerotic cardiovascular diseases(ASCVD)in patients with chronic inflammatory disorders,particularly those afflicted with inflammatory bowel disease(IBD).This review delves into the epidemiological connections between IBD and ASCVD,elucidating potential underlying mechanisms.Furthermore,it discusses the impact of current IBD treatments on cardiovascular risk.Additionally,the cardiovascular adverse effects of novel small molecule drugs used in moderate-to-severe IBD are investigated,drawing parallels with observations in patients with rheumatoid arthritis.This article aims to comprehensively evaluate the existing evidence supporting these associations.To achieve this,we conducted a meticulous search of PubMed,spanning from inception to August 2023,using a carefully selected set of keywords.The search encompassed topics related to IBD,such as Crohn’s disease and ulcerative colitis,as well as ASCVD,including coronary artery disease,cardiovascular disease,atrial fibrillation,heart failure,conduction abnormalities,heart blocks,and premature coronary artery disease.This review encompasses various types of literature,including retrospective and prospective cohort studies,clinical trials,meta-analyses,and relevant guidelines,with the objective of providing a comprehensive overview of this critical intersection of inflammatory bowel disease and cardiovascular health.

关 键 词：Inflammatory bowel diseases Cardiovascular disorders PERICARDITIS MYOCARDITIS THROMBOEMBOLISM Chronic inflammation Oxidative stress Endothelial dysfunction 

分 类 号：R54[医药卫生—心血管疾病]