鹿茸皮肤再生视阈下鹿茸源性物质在伤口愈合领域的潜力分析  

Potential Analysis of Antler-derived Substances in Wound Healing under the Threshold of Antler Skin Renewal

作　　者：罗静龙 肖丽 杨玲 陈春燕 那艳 谭冬玲 黎夏瑶 方彰胜 张伟 LUO Jinglong;XIAO Li;YANG Ling;CHEN Chunyan;NA Yan;TAN Dongling;LI Xiayao;FANG Zhangsheng;ZHANG Wei(Guangdong Eco-Engineering Polytechnic,Guangzhou Guangdong 510520,China;Guangdong Laboratory Animals Monitoring Institute,Guangzhou Guangdong 510260,China;Guangdong Provincial Key Laboratory of Laboratory Animals,Guangzhou Guangdong 510260,China)

机构地区：[1]广东生态工程职业学院,广东广州510520 [2]广东省实验动物科研监测所,广东广州510260 [3]广东省实验动物重点实验室,广东广州510260

出　　处：《现代畜牧科技》2023年第11期104-107,共4页Modern Animal Husbandry Science & Technology

基　　金：广东省普通高校特色创新项目(2022KTSCX284)。

摘　　要：皮肤创伤愈合是一个复杂的过程,在最佳条件下,愈合过程仍然会导致纤维化或疤痕。鹿茸是哺乳动物中唯一可完全再生的附属器官,再生过程中鹿茸实现了巨型创伤到无痕愈合的再生性完美修复。在动物伤口模型中,通过直接注射鹿茸干细胞、局部应用鹿茸干细胞分泌因子或者鹿茸提取物均可以实现伤口的快速愈合。鹿茸皮肤再生视阈下通过对鹿茸源性物质在伤口愈合领域的潜力分析与全面了解,可为该领域基础研究和临床治疗提供新理论和新手段,同时为探索中药鹿茸的现代临床药用途径提供实验依据。Wound healing is a complex process that can still lead to fibrosis or scarring under optimal conditions.Deer antlers are an exception and can fully regenerate annually in postnatal mammals.During the regeneration process,antler achieves a regenerative and perfect repair from giant wounds to traceless healing.In animal models,wound healing can be achieved by the direct injection of antler stem cells(AnSCs),topical application of conditioned medium of AnSCs and other antler-derived substances.A more comprehensive understanding of antler-derived substances will lay the foundation for exploiting basic research and developing an effective clinical therapy for wound healing.At the same time,it provides a basis for exploring the modern clinical medicinal pathways of Chinese medicine deer antler velvet.

关 键 词：鹿茸 干细胞 鹿茸源性物质 皮肤再生 伤口愈合 

分 类 号：S825[农业科学—畜牧学]