针刺联合耳穴压豆治疗绝经后女性高血压失眠的临床观察  

Clinical Observation on Acupuncture Combined with Auricular Point Seed-Pressing in the Treatment of Postmenopausal Women with Hypertension and Insomnia

作　　者：赵钰琦 应晓明[2] 许嘉隆 郭少卿[2] ZHAO Yu-Qi;YING Xiao-Ming;XU Jia-Long;GUO Shao-Qing(Zhejiang Chinese Medical University,Hangzhou 310053 Zhejiang,China;The Third Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310053 Zhejiang,China)

机构地区：[1]浙江中医药大学,浙江杭州310053 [2]浙江中医药大学附属第三医院,浙江杭州310053

出　　处：《广州中医药大学学报》2023年第12期3096-3102,共7页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：浙江省医药卫生科研计划项目(编号:2020KY479)。

摘　　要：【目的】观察针刺联合耳穴压豆治疗绝经后女性高血压失眠的临床疗效。【方法】将98例绝经后女性高血压失眠心肾不交证患者随机分为观察组和对照组,每组各49例,对照组给予艾司唑仑片口服,观察组在对照组治疗的基础上,给予针刺联合耳穴压豆治疗,连续治疗4周。治疗1个月后,观察2组患者治疗前后匹兹堡睡眠质量指数(PSQI)评分的变化情况,以及血清miR-223、miR-146a水平的情况,比较2组患者治疗前后外周血CD3^(+)、CD4^(+)、CD8^(+)T细胞水平的变化情况。【结果】(1)治疗后,2组患者的PSQI评分明显改善(P<0.05),且观察组在改善PSQI评分方面明显优于对照组,差异有统计学意义(P<0.05)。(2)治疗后,2组患者的血清miR-223、miR-146a水平明显改善(P<0.05),且观察组在改善血清miR-223、miR-146a水平方面明显优于对照组,差异有统计学意义(P<0.05)。(3)治疗后,2组患者的外周血CD3^(+)、CD4^(+)、CD8^(+)T细胞水平明显改善(P<0.05),且观察组在改善外周血CD3^(+)、CD4^(+)、CD8^(+)T细胞水平方面明显优于对照组,差异有统计学意义(P<0.05)。【结论】针刺联合耳穴压豆治疗绝经后女性高血压失眠,能明显改善绝经后女性高血压患者的失眠症状,提高免疫功能,降低miR-223、miR-146a水平,疗效显著。Objective To investigate the clinical efficacy of acupuncture combined with auricular point seedpressing in the treatment of postmenopausal women with hypertension and insomnia.Methods Ninety-eight postmenopausal female patients with hypertension and insomnia of incoordination between heart and kidney were randomly divided into observation group and control group,with 49 cases in each group.The control group was given Estazolam Tablets,and the observation group was given acupuncture combined with auricular point seedpressing on the basis of the treatment of the control group,and was treated for 4 consecutive weeks.After 1 month of treatment,the changes in Pittsburgh Sleep Quality Index(PSQI)scores and serum miR-223 and miR-146a levels were observed before and after treatment in the two groups.The changes in peripheral blood CD3^(+),CD4^(+),CD8^(+)T cell levels were compared between the two groups of patients before and after treatment.Results(1)After treatment,the PSQI scores of the two groups of patients were significantly improved(P<0.05),and the observation group was significantly superior to the control group in improving the PSQI scores,and the difference was statistically significant(P<0.05).(2)After treatment,the serum miR-223 and miR-146a levels of patients in the two groups were significantly improved(P<0.05),and the observation group was significantly superior to the control group in improving serum miR-223 and miR-146a levels,and the difference was statistically significant(P<0.05).(3)After treatment,the peripheral blood CD3^(+),CD4^(+),CD8^(+)T-cell levels of the two groups of patients were significantly improved(P<0.05),and the observation group was significantly superior to the control group in improving the peripheral blood CD3^(+),CD4^(+),CD8^(+)T-cell levels,and the difference was statistically significant(P<0.05).Conclusion Acupuncture combined with auricular point seed-pressing for the treatment of insomnia in postmenopausal women with hypertension can significantly improve the insomnia symptom

关 键 词：针刺 耳穴压豆 绝经后高血压 失眠 心肾不交 miR-223 MIR-146A 临床观察 

分 类 号：R246.9[医药卫生—针灸推拿学]