基于岗藿抗感汤辨治新型冠状病毒感染的临床研究  

Clinical Study on Ganghuo Kanggan Decoction for the Treatment of Novel Coronavirus Infection

作　　者：许国博 徐卫方[1] 高运吉 张瑞[1] 张羽若 XU Guo-Bo;XU Wei-Fang;GAO Yun-Ji;ZHANG Rui;ZHANG Yu-Ruo(Shenzhen Hospital of Guangzhou University of Chinese Medicine,Shenzhen 518000 Guangdong,China)

机构地区：[1]广州中医药大学深圳医院,广东深圳518000

出　　处：《广州中医药大学学报》2023年第11期2744-2749,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20211136)。

摘　　要：【目的】探讨岗藿抗感汤治疗新型冠状病毒感染的临床疗效及其安全性。【方法】将72例新型冠状病毒感染湿毒郁肺型患者随机分为常规治疗组和岗藿抗感汤组,每组各36例。常规治疗组给予常规西医治疗(包括吸氧、抗病毒、抗菌等),岗藿抗感组在常规治疗组的基础上联合岗藿抗感汤加减治疗,疗程为1周。观察2组患者治疗前后中医证候积分、相关炎症指标及Borg自觉疲劳评分的变化情况,比较2组患者的病毒转阴时间,评估2组的临床疗效和安全性。【结果】(1)治疗1周后,2组患者的总有效率均为100.00%(36/36),组间比较(Fisher精确概率法),差异无统计学意义(P>0.05)。(2)治疗后,2组患者的中医证候积分、Borg自觉疲劳评分均较治疗前明显降低(P<0.01),淋巴细胞计数(LYM)及淋巴细胞百分比(LYM%)均较治疗前明显升高(P<0.01),且岗藿抗感汤组对中医证候积分、Borg自觉疲劳评分的降低幅度及对LYM及LYM%的升高幅度均明显优于常规治疗组,差异均有统计学意义(P<0.01)。(3)2组患者新型冠状病毒核酸检测全部转阴,转阴率均为100.00%;其中常规治疗组最短转阴时间为3 d,最长转阴时间为7 d,平均转阴时间为5.28 d,中位转阴时间为6 d;岗藿抗感汤组最短转阴时间为3 d,最长转阴时间为7 d,平均转阴时间为5.03 d,中位转阴时间为5 d。组间比较,差异无统计学意义(P>0.05)。(4)住院期间,2组患者均未出现严重不良事件,均痊愈出院。【结论】岗藿抗感汤治疗新型冠状病毒感染湿毒郁肺型患者疗效确切,能有效提升外周血淋巴细胞水平,增强机体免疫力,降低Borg自觉疲劳评分,改善患者中医证候,且具有较高的安全性。Objective To investigate the clinical efficacy and safety of Ganghuo Kanggan Decoction for the treatment of novel coronavirus infection(also known as COVID-19).Methods Seventy-two patients with COVID-19 of damp-toxin trapping lung type were randomly divided into conventional treatment group and Ganghuo Kanggan Decoction group,with 36 cases in each group.The conventional treatment group was given conventional western medical treatment(including oxygen inhalation,antiviral treatment,antibacterial treatment,etc.),and Ganghuo Kanggan Decoction group was given modified Ganghuo Kanggan Decoction orally on the basis of the conventional treatment group,and the course of treatment covered one week.The changes of traditional Chinese medicine(TCM)syndrome scores,inflammation-related indicators and Borg fatigue scores were observed in the two groups before and after treatment,the nucleic acid negative-conversion time in the two groups was compared,and the clinical efficacy and safety of the two groups were evaluated.Results(1)After one week of treatment,the total effective rate in the two groups was all 100.00%(36/36),and the intergroup comparison(tested by Fisher’s precision probability method)showed that the difference was not statistically significant(P>0.05).(2)After treatment,the TCM syndrome scores and Borg fatigue scores in the two groups were significantly decreased compared with those before treatment(P<0.01),and the lymphocyte(LYM)count and lymphocyte percentages(LYM%)were significantly increased compared with those before treatment(P<0.01),and the Ganghuo Kanggan Decoction group had stronger effect on the decrease of the TCM syndrome scores and Borg fatigue scores and on the increase of LYM count and LYM%than the conventional treatment group,the differences being statistically significant(P<0.01).(3)The nucleic acid test of COVID-19 in the two groups was all negative,with a negative-conversion rate of 100.00%.In the conventional treatment group,the shortest negative-conversion time was 3 days,the longest negativ

关 键 词：岗藿抗感汤 新型冠状病毒感染 湿毒郁肺 炎症指标 中医证候积分 

分 类 号：R254.3[医药卫生—中医内科学]