氟致脾脏免疫功能损伤相关信号通路的研究进展  

Research progress on signaling pathways related to fluoride induced spleen immune function damage

作　　者：刘阳阳 赵巧湜 Liu Yangyang;Zhao Qiaoshi(Center for Endemic Disease Control,Chinese Center for Disease Control and Prevention,National Health Commission&Education Bureau of Heilongjiang Province,Key Laboratory of Etiology and Epidemiology,Heilongjiang Provincial Key Laboratory of Trace Elements and Human Health,Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学中国疾病预防控制中心地方病控制中心、国家卫生健康委病因流行病学重点实验室、黑龙江省高校病因流行病学重点实验室、黑龙江省微量元素与人类健康重点实验室,哈尔滨150081

出　　处：《中华地方病学杂志》2023年第11期942-946,共5页Chinese Journal of Endemiology

基　　金：黑龙江省自然科学基金(LH2023H014);黑龙江省普通本科高等学校青年创新人才培养计划(UNPYSCT-2017058)。

摘　　要：氟在自然界中广泛存在,机体长期摄入过量的氟会引起牙齿、骨骼等骨相组织以及神经、心血管、消化、免疫系统等多种非骨相组织或器官损伤。氟可通过引起脾脏淋巴细胞的凋亡和自噬,最终造成脾脏结构和功能的损伤。本文对氟致脾脏免疫功能损伤相关信号通路的研究进展进行综述,以期为其分子机制研究提供理论依据。Fluorine is widely present in nature,and long-term excessive intake of fluoride by the body can cause damages to bone tissues such as teeth and bones,as well as non bone tissues and organs such as nervous,cardiovascular,digestive and immune systems.Fluoride can cause apoptosis and autophagy of spleen lymphocytes,ultimately leading to damage to the structure and function of spleen.This article reviews the research progress of signaling pathways related to fluoride induced spleen immune function damage,in order to provide a theoretical basis for molecular mechanism study.

关 键 词：氟 脾脏 淋巴细胞 免疫功能 信号通路 

分 类 号：R114[医药卫生—卫生毒理学]