复宫宁颗粒联合曲普瑞林治疗子宫内膜异位症临床观察  

Clinical observation on the treatment of endometriosis with fugongning granules combined with triptorelin

作　　者：李晓娟 刘晓妍 王淑娜 高慧[1] LI Xiaojuan;LIU Xiaoyan;WANG Shuna;GAO Hui(Department of Obstetrics and Gynecology,Henan Hongli Hospital,Chang yuan,Henan 453400,China;Department of Gynecology,Zhengzhou People's Hospital,Zhengzhou,Henan 453000,China;Department of Assisted Reproduction,Henan Provincial People's Hospital,Zhengzhou,Henan 453000,China)

机构地区：[1]河南宏力医院妇产科,河南长垣453400 [2]郑州人民医院妇科,河南郑州453000 [3]河南省人民医院辅助生殖科,河南郑州453000

出　　处：《社区医学杂志》2023年第23期1240-1244,共5页Journal Of Community Medicine

摘　　要：目的探讨复宫宁颗粒联合曲普瑞林治疗子宫内膜异位症(EMT)有效性及对血清人类白细胞抗原-G(HLA-G)、多配体蛋白聚糖-1(SDC-1)影响。方法选取2019-05-01-2022-01-01河南宏力医院收治的148例EMT患者作为研究对象,以随机数字表法分为观察组和对照组,各74例。对照组予以曲普瑞林治疗,观察组基于对照组联用复宫宁颗粒治疗。比较2组总有效率、视觉模拟评分法(VAS)、Kuppperman指数(KI)、子宫内膜异位囊肿直径、性激素[黄体生成素(LH)、雌二醇(E_(2))、卵泡雌激素(FSH)],病情相关指标[HLA-G、SDC-1、卵泡抑制素(FS)、可溶性白细胞介素2受体(SIL-2R)水平]及不良反应。结果观察组总有效率为93.24%,高于对照组的81.08%,χ^(2)=4.891,P=0.027。治疗后观察组KI、VAS评分分别为(7.62±1.11)、(1.62±0.46)分,低于对照组的(9.37±1.35)、(2.31±0.63)分;囊肿直径为(22.34±2.15)mm,短于对照组的(25.46±2.30)mm,F值分别为6.025、5.851和6.554,均P<0.001。治疗后观察组LH、FSH水平分别为(7.18±1.25)、(3.15±0.57)IU/L,低于对照组的(9.41±1.49)、(4.19±0.63)IU/L;E_(2)水平为(718.65±28.75)pg/mL,高于对照组的(614.27±26.83)pg/mL,F值分别为8.645、21.623和4.587,均P<0.001。治疗后观察组SIL-2R、SDC-1、HLA-G、FS水平分别为(246.67±15.27)ng/mL、(1562.37±84.36)μg/L、(5.81±1.24)μg/L、(238.41±17.65)ng/L,低于对照组的(289.54±17.13)ng/mL、(1927.45±91.25)μg/L、(6.77±1.36)μg/L、(281.83±19.15)ng/L,F值分别为18.692、55.850、6.653和35.627,均P<0.001。观察组不良反应发生率为5.40%,对照组为12.16%,差异无统计学意义,χ^(2)=2.108,P=0.245。结论复宫宁颗粒联合曲普瑞林治疗EMT效果显著,能有效减轻患者疼痛,缓解临床症状,调节机体性激素水平,调控HLA-G和SDC-1表达。Objective To investigate the efficacy of Fugongning granules combined with triprerelin in the treatment of endometriosis(EMT)and its impact on serum human leukocyte antigen G(HLA-G)and syndecan-1(SDC-1).Methods A total of 148 patients with EMT treated from May 1,2019 to January 1,2022 in Henan Hongli Hospital were selected as the study objects,and they were divided into observation group and control group by random number table method,with 74 cases in each group.The control group was treated with triprorelin,and the observation group was treated with Fugongning granule.The total effective rate,visual analogue scale(VAS),Kuppperman index(KI),endometriosis cyst diameter,sex hormones(LH),estradiol(E_(2)),follicle estrogen(FSH)),disease-related indicators[HLA-G,SDC-1,follicle statin(FS),soluble interleukin-2 receptor(SIL-2R)levels] and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 93.24%,higher than 81.08%of the control group,with χ^(2)=4.891 and P=0.027.After treatment,the KI and VAS scores of the observation group were(7.62±1.11)and(1.62±0.46),respectively,lower than those of the control group(9.37±1.35)and(2.31±0.63);The diameter of the cyst was(22.34±2.15)mm,which was shorter than the control group's(25.46±2.30)mm.The F-values were 6.025,5.851 and 6.554,respectively,all P<0.001.After treatment,the LH and FSH levels in the observation group were(7.18±1.25)and(3.15±0.57)IU/L,respectively,lower than those in the control group(9.41±1.49)and(4.19±0.63)IU/L;The E_(2) level was(718.65±28.75)pg/ml,which was higher than the control group's(614.27±26.83)pg/ml,with F-values of 8.645,21.623 and 4.587,respectively,all P<0.001.After treatment,the levels of SIL-2R,SDC-1,HLA-G and FS in the observationgroupwere(246.67±15.27)ng/ml,(1562.37±84.36)μg/L,(5.81±1.24)μg/Land(238.41±17.65)ng/L,lower than the control group's(289.54±17.13)ng/ml,(1927.45±91.25)μg/L,(6.77±1.36)μg/L and(281.83±19.15)ng/L,with F-values of 18.692,55.850,6.653 and 35

关 键 词：子宫内膜异位症 复宫宁颗粒 曲普瑞林 人类白细胞抗原-G 多配体蛋白聚糖-1 

分 类 号：R711.71[医药卫生—妇产科学]