火麻仁辅助治疗儿童功能性便秘临床研究  

Clinical Study on Adjuvant Treatment of Cannabis Fructus for Children with Functional Constipation

作　　者：陈斯琼 李威 钟蒙蒙 CHEN Siqiong;LI Wei;ZHONG Mengmeng(Department of Pediatrics,Wenzhou Integrated Traditional Chinese and Western Medicine Hospital,Wenzhou Zhejang 325000,China)

机构地区：[1]温州市中西医结合医院儿科,浙江温州325000

出　　处：《新中医》2023年第21期104-107,共4页New Chinese Medicine

摘　　要：目的:观察火麻仁辅助治疗儿童功能性便秘的临床疗效及对肠道功能的影响。方法:选取住院治疗的功能性便秘患儿78例,以随机数字表法分为对照组、观察组各39例。对照组给予乳果糖联合饮食疗法治疗,观察组在对照组基础上给予火麻仁辅助治疗,2组疗程均为4周。比较2组治疗前后便秘症状改善指标、胃肠动力学指标、胃肠激素水平;比较2组临床疗效及便秘复发率。结果:治疗后,观察组总有效率92.31%,高于对照组74.36%(P<0.05)。治疗后,2组排便疼痛、便质干硬、每天排便次数<1次占比均较治疗前降低(P<0.05);且观察组治疗后排便疼痛、便质干硬、每天排便次数<1次占比低于对照组(P<0.05)。治疗后,2组直肠最低敏感量、直肠最大耐受量、肛门括约肌最大收缩压及血清胃泌素(GAS)、血管活性肠肽(VIP)水平均较治疗前降低(P<0.05),血清P物质(SP)水平均升高(P<0.05);观察组治疗后直肠最低敏感量、直肠最大耐受量、肛门括约肌最大收缩压及血清GAS、VIP水平均低于对照组(P<0.05),血清SP水平高于对照组(P<0.05)。随访2个月,观察组复发率5.56%,低于对照组34.48%(P<0.05)。结论:火麻仁辅助治疗儿童功能性便秘疗效确切,能够改善患者胃肠动力学,恢复胃肠激素水平,降低便秘复发率。Objective:To observe the clinical effect of adjuvant treatment of Cannabis Fructus for children with functional constipation and its effect on intestinal function.Methods:A total of 78 hospitalized children with functional constipation were selected and randomly divided into the control group and the observation group,with 39 cases in each group.The control group was treated with lactose combined with dietary therapy,and the observation group received adjuvant treatment with Cannabis Fructus based on the treatment of the control group.Both groups were given a 4-week treatment course.The improvement of constipation symptoms,gastrointestinal motility indicators,and gastrointestinal hormone levels were compared between the two groups before and after treatment.The clinical effects and recurrence rates of constipation were compared between the two groups.Results:After treatment,the total effective rate was 92.31%in the observation group,higher than that of 74.36%in the control group(P<0.05).After treatment,the proportion of constipation pain,dry and hard stools,and frequency of bowel movements less than once per day in the two groups were decreased when compared with those before treatment(P<0.05);the constipation pain,dry and hard stools,and frequency of bowel movements less than once per day in the observation group were lower than those in the control group(P<0.05).After treatment,the minimum sensitivity maximum tolerance,maximum systolic pressure of the anal sphincter,the serum vasoactive intestinal peptide(VIP),and serum gastrin(GAS)levels in both groups were decreased compared with those before treatment(P<0.05),and substance P(SP)levels were increased(P<0.05);after treatment,the minimum sensitivity,maximum tolerance,maximum systolic pressure of the anal sphincter and serum VIP,GAS levels in the observation group were lower than those in the control group(P<0.05),and the serum SP levels was higher than those in the control group(P<0.05).After a 2-month follow-up,the recurrence rate was 5.56%in the observation g

关 键 词：儿童功能性便秘 火麻仁 胃泌素 血管活性肠肽 P物质 胃肠动力学 

分 类 号：R723.11[医药卫生—儿科] R72[医药卫生—临床医学]