清热解毒汤联合伐昔洛韦治疗复发性生殖器疱疹临床研究  

Clinical Study on Qingre Jiedu Decoction Combined with Valaciclovir for Recurrent Genital Herpes

作　　者：方慧倩 方梦婕 FANG Huiqian;FANG Mengjie(Department of Dermatology,The First People's Hospital of Chun'an County,Hangzhou Zhejiang 311700,China)

机构地区：[1]淳安县第一人民医院皮肤科,浙江杭州311700

出　　处：《新中医》2023年第21期108-112,共5页New Chinese Medicine

摘　　要：目的:观察清热解毒汤联合伐昔洛韦治疗复发性生殖器疱疹(RGH)的临床疗效。方法:选取84例RGH患者,按随机数字表法分为治疗组44例与对照组40例。对照组给予伐昔洛韦治疗,治疗组给予清热解毒汤联合伐昔洛韦治疗,2组均连续治疗10 d。观察2组临床疗效、疱疹愈合时间及复发率,比较2组治疗前后生殖器疱疹症状积分、免疫功能的变化。结果:治疗后,2组生殖器疱疹症状积分均较治疗前下降(P<0.05),治疗组生殖器疱疹症状积分低于对照组(P<0.05)。治疗组临床疗效总有效率为93.18%,对照组为77.50%,2组比较,差异有统计学意义(P<0.05)。治疗后,治疗组止疱时间、结痂时间、脱痂时间均早于对照组(P<0.05)。治疗后,2组CD3^(^(+))、CD4^(^(+))、CD4^(^(+))/CD8^(^(+))水平均较治疗前升高,CD8^(^(+))水平均较治疗前下降,治疗组前后比较,差异有统计学意义(P<0.05);治疗组CD3^(^(+))、CD4^(^(+))、CD4^(^(+))/CD8^(^(+))水平均高于对照组(P<0.05),CD8^(^(+))水平低于对照组(P<0.05)。治疗组复发率为4.88%,对照组复发率为22.58%,2组比较,差异有统计学意义(P<0.05)。结论:清热解毒汤联合伐昔洛韦治疗RGH疗效显著,可缓解临床症状,促进疱疹愈合,提高机体免疫力及降低复发率。Objective:To observe the clinical effect of the therapy of Qingre Jiedu Decoction combined with valaciclovir on recurrent genital herpes(RGH).Methods:A total of 84 RGH patients were selected and divided into two groups according to random number table method,with 44 cases in the treatment group and 40 cases in the control group.The control group was treated with Valaciclovir,and the treatment group was treated with Qingre Jiedu Decoction combined with Valaciclovir.Both groups were treated for 10 days.The clinical effects,herpes healing time and recurrence rates in the two groups were observed.The changes of genital herpes symptom scores and immune function were compared before and after treatment between the two groups.Results:After treatment,the genital herpes symptom scores in the two groups were decreased when compared with those before treatment(P<0.05),and the genital herpes symptom scores in the treatment group were lower than those in the control group(P<0.05).The total effective rate was 93.18%in the treatment group and 77.50%in the control group,the difference being significant(P<0.05).After treatment,the time of herpes stopping growth,scab time and scab removal time in the treatment group were earlier than those in the control group(P<0.05).After treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups were increased when compared with those before treatment,and the levels of CD8^(+)were decreased when compared with those before treatment,difference being significant(P<0.05);the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the treatment group were higher than those in the control group(P<0.05),and the CD8^(+)level was lower than that in the control group(P<0.05).The recurrence rate was 4.88%in the treatment group and 22.58%in the control group,the difference being significant(P<0.05).Conclusion:The therapy of Qingre Jiedu Decoction combined with Valaciclovir has a significant therapeutic effect on RGH,which can relieve clinical symptoms,promote the healing of herpes,improve immunity

关 键 词：复发性生殖器疱疹 清热解毒汤 伐昔洛韦 免疫功能 复发率 

分 类 号：R752.1[医药卫生—皮肤病学与性病学]