安徽省成年居民血尿酸水平与代谢综合征关系的研究  

Association between serum uric acid and metabolic syndrome among adult residents in Anhui province

作　　者：徐伟[1] 王华东[1] 邢秀雅[1] 许精巧 曹丹[1] 程倩瑶 吕逸丽 刘志荣[1] Xu Wei;Wang Huadong;Xing Xiuya;Xu Jingqiao;Cao Dan;Cheng Qianyao;Lyu Yili;Liu Zhirong(Department of Chronic Non-communicable Diseases of Anhui Provincial Center for Disease Control and Prevention,Public Health Research Institute of Anhui Province,Hefei 230601,China)

机构地区：[1]安徽省疾病预防控制中心慢性非传染性疾病防治科,安徽省公共卫生研究院,合肥230601

出　　处：《中华内分泌代谢杂志》2023年第10期865-869,共5页Chinese Journal of Endocrinology and Metabolism

基　　金：中央财政转移支付地方重大公共卫生服务项目(Z135080000022)。

摘　　要：目的利用2018年安徽省中国成人慢性病与营养监测数据,比较不同特征成年居民代谢综合征(MS)患病率,分析血清尿酸(serum uric acid,SUA)水平与MS的关系。方法采用多阶段分层整群随机抽样方法,选取≥18岁居民进行询问调查、身体测量和实验室检测。使用复杂加权方法估算不同特征居民的MS患病率,采用复杂抽样数据的logistic回归模型分析SUA与MS患病风险的关系,利用受试者工作特征(ROC)曲线评估SUA诊断MS的可靠性和最佳切点。结果共纳入7182人,成年居民MS患病率为29.46%,女性MS患病率(33.76%)高于男性(25.28%),差异有统计学意义(P<0.05)。校正其他因素后,SUA每增加10μmol/L,男性居民MS患病风险增加4.0%(OR=1.040,95%CI 1.019~1.061),女性居民MS患病风险增加7.0%(OR=1.070,95%CI 1.059~1.082)。SUA诊断MS的曲线下面积(AUC)为0.816(95%CI 0.806~0.826),灵敏度为0.761,特异度为0.727,最佳切点为450μmol/L。结论安徽省成年居民MS患病率为29.46%,SUA是MS患病的危险因素,SUA水平增加提示MS患病率升高,SUA水平的最佳切点值可能有助于MS的诊断。Objective To investigate the prevalence of metabolic syndrome(MS)among adult residents with different characteristics and the relationship between serum uric acid(SUA)level and MS using the data of Chinese Adult Chronic Diseases and Nutrition Surveillance(2018)program in Anhui.Methods Multi-stage stratified cluster random sampling was used to select participants aged 18 and over for questionnaires,physical measurements,and laboratory tests.The complex weighted method was used to estimate the prevalence of MS among residents with different characteristics.Logistic regression model based on complex sampling data was used to analyze the relationship between SUA and MS.Receiver operating characteristic(ROC)curve was used to evaluate the reliability of SUA in diagnosing MS and determine the optimal cutoff point.Results A total of 7182 participants were included and the prevalence of MS among adult residents was 29.46%.The prevalence of MS was higher in females(33.76%)than that in males(25.28%),and the difference was statistically significant(P<0.05).After adjusting for other factors,for every 10μmol/L increase in SUA,the risk of MS increased by 4%in males(OR=1.040,95%CI 1.019-1.061)and 7%in females(OR=1.070,95%CI 1.059-1.082).The area under the curve(AUC)for SUA in diagnosing MS was 0.816(95%CI 0.806-0.826),with a sensitivity of 0.761 and specificity of 0.727.The optimal cutoff point for SUA was 450μmol/L.Conclusion The prevalence of MS among adult residents in Anhui Province is 29.46%.SUA is a risk factor for MS,and increasing SUA level indicated a higher risk of MS.The optimal cutoff value of SUA may be helpful in diagnosing MS.

关 键 词：代谢综合征 血尿酸 成年居民 横断面调查 

分 类 号：R589[医药卫生—内分泌]