专利视角下体外膜肺氧合(ECMO)氧合膜技术发展态势  

On the development trend of oxygenation membrane technologyfor extracorporeal membrane oxygenation(ECMO) from a perspectiveof patents

作　　者：何俊卿 陈思思 程荣[1] 徐慧芳[2,3] 郑祥 HE Junqing;CHEN Sisi;CHENG Rong;XU Huifang;ZHENG Xiang(School of Environment and Natural Resources,Renmin University of China,Beijing 100872,China;Documentation&Information Center,Chinese Academy of Sciences,Beijing 100190,China;Department of Library,Information and Archives Management,School of Economics and Management,University of Chinese Academy of Sciences,Beijing 100190,China)

机构地区：[1]中国人民大学环境学院,北京100872 [2]中国科学院文献情报中心,北京100190 [3]中国科学院大学经济与管理学院图书情报与档案管理系,北京100190

出　　处：《科技导报》2023年第21期98-113,共16页Science & Technology Review

基　　金：国家自然科学基金项目(52070192)。

摘　　要：以在Incopat专利数据平台检索的全球体外膜肺氧合(extracorporeal membrane oxygen⁃ation,ECMO)氧合膜领域专利为原始样本,从专利视角分析了ECMO氧合膜技术发展轨迹和趋势、全球市场布局及技术布局。结果表明新冠疫情一定程度上刺激了氧合膜技术的发展。中国是ECMO氧合膜领域全球第3大专利申请来源国和布局国,也是重要的目标市场,但是高价值专利占比不高。中国专利除了少数涉及膜制备改性、膜组件与制膜装置外,大部分涉及氧合器优化设计及相关辅助技术,且大多为实用新型专利。ECMO用中空纤维膜的制备方法及优化工艺、新型聚合物材料、膜材料表面改性和复合膜研究是当下的热点方向。Extracorporeal membrane oxygenation(ECMO)is an effective extracorporeal life support measure that played a crucial role in the treatment of critically patients with COVID-19.However,its core component,oxygenation membrane for ECMO,has been monopolized by foreign countries for a long time.This study used the Incopat and retrieved form it the patents in the field of oxygenated membranes for ECMO worldwide,which were then analyzied as the original data to disclose the trend and trajectory of technology development,the layout of global market and technology from the perspective of patents.The result shows that COVID-19 has stimulated the development of technology.China becomes the world's third largest source and distribution of patent applications in the field as well as an important target market,but its high-value patents account for a small proportion.Except for a few patents related to membrane preparation and its device,membrane modification,and membrane module,most of the Chinese patents involve the optimal design of oxygenator and related auxiliary technologies,and most of them are utility model patents.The preparation method and optimization process of hollow fiber membrane for ECMO,new polymer materials,membrane modification and composite membrane research are the current hot research topics.Recently Chinese patents reported the preparation technology of PMP hollow fiber membranes for ECMO and related devices,which are expected to achieve a breakthrough in the preparation technology of high-performance PMP hollow fiber membranes.Innovations can be made for the existing defects of polymer material synthesis technology and membrane preparation technology.Meanwhile,it is necessary to increase the research of biocompatibility modification technology and find new materials with better performance to achieve technological breakthrough.Promoting the localization of oxygenation membranes for ECMO will help the localization of ECMO systems.

关 键 词：体外膜肺氧合(ECMO) 氧合膜 专利分析 发展态势 

分 类 号：R459.7[医药卫生—急诊医学]