住院发热患者300例血培养病原菌及耐药性分析  

Pathogenic bacteria and drug resistance in 300 hospitalized fever patients with positive blood culture results

作　　者：王娜 樊伟继 韩晴晴 Wang Na;Fan Weiji;Han Qingqing(Department of Laboratory,Longhai Hospital,Kaifeng,Henan 475000,China)

机构地区：[1]河南省开封市陇海医院检验科,河南开封475000

出　　处：《实用医技杂志》2023年第9期659-662,共4页Journal of Practical Medical Techniques

摘　　要：目的探究300例住院发热患者血培养病原菌及耐药性。方法收集2018年1月至2023年1月河南省开封市陇海医院收治的住院发热患者血液样本300例。检测发热患者血培养阳性结果病原菌种类,并分析不同抗菌药物对病原菌的耐药性。结果300例住院发热患者血培养阳性结果中革兰阳性菌占比较高(213/300),其中人葡萄球菌、表皮葡萄球菌、金黄色葡萄球菌占比较高。革兰阴性菌中肺炎克雷伯菌及大肠埃希菌占比较高。人葡萄球菌对红霉素、苯唑西林、四环素、克林霉素、磺胺甲恶唑的耐药率较高,金黄色葡萄球菌对红霉素、磺胺甲恶唑、苯唑西林、四环素、左氧氟沙星的耐药率较高,表皮葡萄球菌对红霉素、磺胺甲恶唑、苯唑西林、克林霉素、环丙沙星的耐药率较高。肺炎克雷伯菌对哌拉西林/他唑巴坦、头孢他啶的耐药率较高。大肠埃希菌对氨苄西林、复方磺胺甲恶唑、氨曲南、庆大霉素、头孢噻肟、头孢唑林、左氧氟沙星、头孢吡肟、头孢他啶的耐药率较高。结论300例住院发热患者血培养阳性结果病原菌以革兰阳性菌感染为主。不同病原菌对不同抗菌药的耐药性不同,临床上应及时检测住院发热患者血样药物耐药情况,合理进行抗菌治疗。Objective To investigate the pathogenic bacteria and drug resistance of 300 hospitalized febrile patients with positive blood culture results.Methods A total of 300 blood samples of hospitalized febrile patients admitted to Longhai Hospital in Kaifeng City,Henan Province from January 2018 to January 2023 were collected.The types of pathogenic bacteria in the positive blood culture results of fever patients were detected,and the drug resistance of different antibacterial drugs to different pathogenic bacteria was analyzed.Results Gram-positive bacteria accounted for a higher proportion of positive blood culture results in 300 hospitalized patients with fever,including Staphylococcus hominis,Staphylococcus epidermidis and Staphylococcus aureus.Among the gram-negative bacteria,Klebsiella pneumoniae and Escherichia coli accounted for a higher proportion Resistance to erythromycin,benzoxiline,tetracycline,clindamycin,and sulfamethoxazole was higher among human staphylococci,erythromycin,sulfamethoxazole,benzoxiline,tetracycline,and levofloxacin among Staphylococcus aureus,and erythromycin,sulfamethoxazole,benzoxiline,clindamycin,and ciprofloxacin among Staphylococcus epidermidis.The resistance rate of Klebsiella pneumoniae had a high rate of resistance to piperacillin/tazobactam and ceftazidime.The resistance rate of Eschericcoli to ampicillin,compound sulfamethoxazole,amitranam,gentamicin,cefotaxime,cefzolin,levofloxacin,cefepime and ceftazidime was high.Conclusion Gram-positive bacteria were the main pathogenic bacteria in 300 hospitalized patients with fever.The drug resistance of different pathogens to different antibiotics is different,and the drug resistance of blood samples of hospitalized patients with fever should be timely detected for rational antimicrobial treatment in the clinic should be carried out.

关 键 词：住院 发热 血培养 病原菌 耐药性 

分 类 号：R446.5[医药卫生—诊断学]