基于层次分析-熵权法和网络药理学的蓝布正质量标志物研究  

Identification of quality markers of Gei Herba based on analytic hierarchy process-entropy weight method and network pharmacology

作　　者：杨钊 郑治波 周浩明 徐顶巧 乐世俊 唐于平 YANG Zhao;ZHENG Zhi-bo;ZHOU Hao-ming;XU Ding-qiao;YUE Shi-jun;TANG Yu-ping(Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility,Shaanxi University of Chinese Medicine,Xi'an 712046,China)

机构地区：[1]陕西中医药大学陕西省中医药管理局中药配伍重点实验室,陕西西安712046

出　　处：《中国中药杂志》2023年第20期5450-5459,共10页China Journal of Chinese Materia Medica

基　　金：国家重点研发计划项目(2019YFC1711000);2021年省级大学生创新创业训练计划项目(202110716043);陕西中医药大学学科创新团队项目(2019-YL10)。

摘　　要：该研究采用层次分析(analytic hierarchy process,AHP)-熵权法(entropy weight method,EWM)和网络药理学结合的方式筛选蓝布正的潜在质量标志物。基于中药质量标志物的新理念,采用AHP-EWM对蓝布正的质量标志物进行量化辨识。AHP法用于一级指标(要素层)的权重分析,EWM法用于分析二级指标下(控制层)基于文献和实验的数据。此外通过网络药理学构建蓝布正的“成分-靶点-疾病-功效”关联网络,筛选与蓝布正益气健脾、补血养阴、润肺化痰功效关联性较强的成分。将AHP-EWM和网络药理学结果相结合,综合确定鞣花酸、没食子酸、二聚鞣花鞣质G、二聚鞣花鞣质C共4个成分作为蓝布正的潜在质量标志物。该研究采用AHP-EWM和网络药理学相结合的方式,对蓝布正的潜在质量标志物进行筛选,为中药质量标志物的量化评价与辨识提供思路。Analytic hierarchy process(AHP)-entropy weight method(EWM) and network pharmacology were employed to identify the potential quality markers(Q-markers) of Gei Herba.According to the new concept of Q-markers in traditional Chinese medicine(TCM),the AHP-EWM was applied to quantitatively identify the Q-markers of Gei Herba.The AHP was used for the weight analysis of primary indicators(factor layer),and the EWM for the analysis of literature and experimental data of secondary indicators(control layer).In addition,network pharmacology was employed to build the "component-target-disease-efficacy" network for Gei Herba,and the components showing strong associations with the Qi-replenishing,spleen-invigorating,blood-tonifying,Yin-nourishing,lung-moistening,and phlegm-resolving effects of Gei Herba were screened out.According to the results of AHP-EWM and network pharmacology,four components,i.e.,ellagic acid,gallic acid,gemin G,and gemin C,were finally identified as potential Q-markers of Gei Herba.In this study,the AHP-EWM and network pharmacology were employed to screen the Q-markers of Gei Herba,which provided ideas for the quantitative evaluation and identification of Q-markers of TCM.

关 键 词：蓝布正 质量标志物 层次分析-熵权法 网络药理学 

分 类 号：R285[医药卫生—中药学]