新生儿出生早期胆红素监测筛查的研究进展  

Progress on early screening and monitoring of neonatal bilirubin levels

作　　者：郑璐(综述) 王瑾(审校) Zheng Lu;Wang Jin(Department of Neonatology,Children′s Hospital of Fudan University,National Children′s Medical Center,Shanghai 201102,China)

机构地区：[1]国家儿童医学中心,复旦大学附属儿科医院新生儿科,上海201102

出　　处：《国际儿科学杂志》2023年第9期580-583,共4页International Journal of Pediatrics

摘　　要：黄疸是新生儿生后早期入院的主要病因之一。严重的新生儿高胆红素血症可能引起急性胆红素脑病或核黄疸,急性胆红素脑病或核黄疸目前尚缺乏有效治疗。通过监测胆红素水平及时发现需要干预的患儿是新生儿高胆红素血症管理的关键。近年来新生儿出生早期胆红素监测在严重高胆红素血症筛查预防、避免核黄疸发生中起到积极作用,但同时也对如何进行筛查及筛查对干预治疗的利弊、经济效益比等提出新的问题。该文旨在对新生儿期胆红素监测筛查的研究进展进行综述,为指导临床合理开展新生儿胆红素筛查及管理提供依据。Jaundice is a leading cause of neonatal admission in the first few weeks of life.Severe neonatal hyperbilirubinemia can cause acute bilirubin encephalopathy and kernicterus,which currently lacks effective treatment.The primary purpose of screening is timely detection of hyperbilirubinemia requiring intervention in the management of neonatal hyperbilirubinemia.A number of recent studies have shown that bilirubin screening decreased the incidence of extreme hyperbilirubinemia and risk of kernicterus.However,it is also very important to consider the balances of benefits and harms of screening and treatment,and find a convenient and efficient way of screening.This article reviews the studies related to the monitoring and screening of bilirubin in the neonatal period to provide evidence for guiding the rational development of neonatal bilirubin screening and management in clinical work.

关 键 词：黄疸 新生儿 高胆红素血症 

分 类 号：R722.1[医药卫生—儿科]