早产儿坏死性小肠结肠炎的研究进展  

Progress of necrotizing enterocolitis in preterm infants

作　　者：张燕(综述)[1] 冀湧(审校) Zhang Yan;Ji Yong(Shanxi Medical University,Taiyuan 030000,China)

机构地区：[1]山西医科大学,太原030000

出　　处：《国际儿科学杂志》2023年第9期639-642,共4页International Journal of Pediatrics

摘　　要：坏死性小肠结肠炎(necrotizing enterocolitis,NEC)是早产儿常见的胃肠道危急重症,该病病死率高,远期生存质量差。早产儿NEC的发病机制尚不完全清楚,在NEC发生发展过程中有众多危险因素参与,NEC的早期诊断、监测及防治仍是研究难点和热点。该文从NEC的高危因素(早产、肠道菌群定植、肠道喂养)、发病机制中Toll样受体4的作用和肠道微循环的变化、影像学监测(腹部X线片、腹部超声)、防治措施(母乳喂养、益生菌、干细胞治疗)等方面对早产儿NEC的研究进展进行综述。Necrotizing enterocolitis(NEC)is a common and critical gastrointestinal disease in premature infants,with a high motality rate and poor long-term quality of life.The pathogenesis of NEC in preterm infants is not unclear completely,and there are numerous risk factors to participate in the development of NEC.The early diagnosis,monitoring and prevention measures of NEC are still difficult and hot spots.This article reviews the progress of NEC on high-risk factors(preterm birth,colonization of intestinal flora,intestinal feeding),the function of the critical role of Toll-like receptor 4 in pathogenesis,changes in the intestinal microcirculation,imaging monitoring(abdominal X-ray,abdominal ultrasound),prevention and control measures(breastfeeding,probiotics,stem cell therapy).

关 键 词：婴儿 早产 坏死性小肠结肠炎 TOLL样受体4 益生菌 干细胞 

分 类 号：R722.6[医药卫生—儿科]