基于肿瘤相关巨噬细胞的抗肿瘤免疫治疗策略  

Anti-tumor immunotherapy strategy based on tumor associated macrophages

作　　者：罗汝婳 廖秀军 LUO Ruhua;LIAO Xiujun(Department of Pharmacy,Wuhan Hankou Hospital,Hubei Wuhan 430012,China;Department of Colorectal Surgery and Oncology,Key Laboratory of Cancer Prevention and Intervention,Ministry of Education,the Second Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang Hangzhou 310058,China;Cancer Center,Zhejiang University,Zhejiang Hangzhou 310058,China)

机构地区：[1]武汉市汉口医院药学部,湖北武汉430012 [2]浙江大学医学院附属第二医院大肠外科教育部肿瘤预防与预警重点实验室,浙江杭州310058 [3]浙江大学肿瘤研究所,浙江杭州310058

出　　处：《现代肿瘤医学》2023年第23期4455-4462,共8页Journal of Modern Oncology

基　　金：浙江省自然科学基金(编号:LY21H270016)。

摘　　要：肿瘤相关巨噬细胞(tumor associated macrophages,TAMs)是肿瘤微环境(tumor microenvironment,TME)中浸润最广泛的免疫细胞,生物学作用复杂且多样,其可促进肿瘤细胞侵袭转移、肿瘤血管生成以及构建抑制性肿瘤微环境。因此,鉴于这些关键作用开发针对TAMs潜在治疗策略,成为现在癌症研究热点。本文总结了TAMs极化对TME的影响,TAMs功能多样性如抑制性和可塑性,其次重点回顾了针对TAMs在药物开发和临床试验中最新研究进展,最后讨论肿瘤免疫治疗新技术和新方法,旨在为更好地解读肿瘤微环境,为肿瘤治疗提供新思路和最大化治疗效益策略。Tumor associated macrophages(TAMs),the most widely infiltrated immune cells in the tumor microenvironment(TME),have complex and diverse biological roles to promote tumor invasion and metastasis,tumor angiogenesis,and the construction of suppressive tumor microenvironment.Furthermore,given these key roles to develop potential therapeutic strategies became an emerging cancer research hotspot.The paper summarizes the impact of polarization of TAMs on TME,as well as the functional diversity of TAMs such as inhibition and plasticity,and focuses on reviewing the recent research advances on TAMs in drug development and clinical trials.Finally,new technologies and approaches to tumor immunotherapy are discussed with the aim of providing new options for tumor treatment and strategies to maximize therapeutic benefit by better deciphering the TME.

关 键 词：肿瘤微环境 肿瘤相关巨噬细胞 免疫治疗 治疗靶点 肿瘤治疗 

分 类 号：R730.5[医药卫生—肿瘤]