经皮可弯曲椎体后凸成形术治疗骨质疏松性椎体压缩骨折的效果及对疼痛介质的影响  

Clinical Effect of Percutaneous Curved Kyphoplasty in the Treatment of Osteoporotic Vertebral Compression Fracture and Its Influence on Pain Mediators

作　　者：林向晖[1] LIN Xianghui(Sanming Integrated Medicine Hospital,Fujian Province,Sanming 365000,China)

机构地区：[1]福建省三明市中西医结合医院,福建三明365000

出　　处：《中国医学创新》2023年第33期34-38,共5页Medical Innovation of China

摘　　要：目的:探究经皮可弯曲椎体后凸成形术治疗骨质疏松性椎体压缩骨折的临床价值。方法:将2019年10月—2022年3月三明市中西医结合医院的120例骨质疏松性椎体压缩骨折患者根据随机数字表法分为对照组和观察组,各60例。对照组行经皮椎体成形术治疗,观察组行经皮可弯曲椎体后凸成形术治疗。比较两组的总有效率、不良情况总发生率、手术前后的疼痛感[视觉模拟评分法(VAS)]、疼痛介质[前列腺素E_(2)(PGE_(2))及P物质(SP)]、功能状态[Oswestry功能障碍指数(ODI)]及结构参数(Cobb角、椎体前缘及中缘高度与后缘高度的比值)。结果:观察组治疗总有效率显著高于对照组,不良反应总发生率显著低于对照组,差异均有统计学意义(P<0.05)。观察组术后3、7 d及1个月的VAS评分、PGE_(2)、SP及术后1、6个月ODI各方面评分均显著低于对照组,术后1、6个月观察组的结构参数均显著优于对照组,差异均有统计学意义(P<0.05)。结论:经皮可弯曲椎体后凸成形术在骨质疏松性椎体压缩骨折患者中的疗效较好,且对疼痛介质及结构参数的改善效果更好,因此在骨质疏松性椎体压缩骨折患者中的应用价值相对更高。Objective:To investigate the clinical value of percutaneous curved kyphoplasty in the treatment of patients with osteoporotic vertebral compression fracture.Method:A total of 120 patients with osteoporotic vertebral compression fracture in Sanming Integrated Medicine Hospital from October 2019 to March 2022 were divided into the control group and the observation group according to the random number table method,with 60 cases in each group.The control group was treated with percutaneous vertebroplasty,and the observation group was treated with percutaneous curved kyphoplasty.The total effective rate,the total incidence of adverse conditions,pain[visual analogue scale(VAS)],pain mediators[prostaglandin E_(2)(PGE_(2))and substance P(SP)],functional status[Oswestry disability index(ODI)]and structural parameters(Cobb angle,the specific value in hight of anteri or and median height margin with trailing edge height of vertebral body)before and after operation were compared between the two groups.Result:The total effective rate of observation group was significantly higher than that of control group,the total adverse events rate was significantly lower than that of control group,the differences were statistically significant(P<0.05).The VAS score,PGE_(2),SP at 3,7 days and 1 month after operation and ODI at 1 month and 6 months after operation in the observation group were significantly lower than those in the control group,the structural parameters at 1 month and 6 months after operation in the observation group were significantly better than those in the control group(P<0.05).Conclusion:The effect of percutaneous curved kyphoplasty in the patients with osteoporotic vertebral compression fracture is better,and the improvement effect on pain mediators and structural parameters is better,so its application value in the patients with osteoporotic vertebral compression fracture is relatively higher.

关 键 词：经皮可弯曲椎体后凸成形术 骨质疏松性椎体压缩骨折 疼痛介质 结构参数 

分 类 号：R687.3[医药卫生—骨科学]