黄芪颗粒辅助治疗新生儿败血症的临床效果  

Clinical Effect of Huangqi Granules in Adjuvant Treatment of Neonatal Septicemia

作　　者：晁小云 吴媚 余露 李琳[1] 喻聪[1] 郭之强[1] 丁宁[1] CHAO Xiaoyun;WU Mei;YU Lu;LI Lin;YU Cong;GUO Zhiqiang;DING Ning(Jiangxi Provincial Children's Hospital,Nanchang 330038,China;不详)

机构地区：[1]江西省儿童医院,江西南昌330038

出　　处：《中国医学创新》2023年第33期67-71,共5页Medical Innovation of China

基　　金：江西省中医药管理局科技计划项目(2022B229)。

摘　　要：目的:探讨黄芪颗粒辅助治疗新生儿败血症的临床效果。方法:选取2022年8月—2023年5月江西省儿童医院NICU收治的新生儿败血症患儿58例作为研究对象,采用随机数字表法分为对照组(n=28)和观察组(n=30)。对照组采用常规治疗,观察组在对照组的基础上增加黄芪颗粒。治疗7 d后,比较两组患儿临床疗效;记录两组体温恢复正常时间、拒奶消失时间及住院时间;比较治疗前后凝血纤溶功能[血小板计数(PLT)、D-二聚体(D-D)、不成熟中性粒细胞/总中性粒细胞(I/T)]、炎症因子[C反应蛋白(CRP)、降钙素原(PCT)、白细胞计数(WBC)],记录两组治疗期间不良反应发生情况。结果:观察组总有效率高于对照组(P<0.05);观察组体温恢复正常时间、拒奶消失时间、住院时间均短于对照组(P<0.05);治疗后观察组PLT水平高于对照组,D-D、I/T水平均低于对照组(P<0.05);治疗后观察组CRP、PCT、WBC水平均低于对照组(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:黄芪颗粒辅助治疗新生儿败血症能提升临床效果,改善临床症状,减轻炎症反应,改善凝血功能,且具有一定安全性。Objective:To explore the clinical effect of Huangqi Granules in adjuvant treatment of neonatal septicemia.Method:A total of 58 children with neonatal septicemia admitted to NICU of Jiangxi Provincial Children's Hospital from August 2022 to May 2023 were selected as the study objects,and were divided into control group(n=28)and observation group(n=30)according to random number table method.The control group received conventional treatment,and the observation group was added Huangqi Granules on the basis of the control group.After 7 days of treatment,the clinical efficacy of the two groups was compared.The body temperature recovery time,milk rejection disappearance time and hospital stay of the two groups were recorded.Coagulation and fibrinolytic function[platelet count(PLT),D-dimer(D-D),immature neutrophil/total neutrophil(I/T)],inflammatory factors[C reactive protein(CRP),procalcitonin(PCT)and white blood cell count(WBC)]were compared before and after treatment,and the occurrence of adverse reactions during treatment in the two groups were recorded.Result:The total effective rate of observation group was higher than that of control group(P<0.05).The body temperature recovery time,milk rejection disappearance time and hospital stay in the observation group were shorter than those in the control group(P<0.05).After treatment,PLT level in observation group was higher than that in control group,D-D and I/T levels in observation group were lower than those in control group(P<0.05).After treatment,the levels of CRP,PCT and WBC in observation group were lower than those in control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Huangqi Granules in adjuvant treatment of neonatal septicemia can improve clinical effect,improve clinical symptoms,reduce inflammatory reaction,improve coagulation function,and has certain safety.

关 键 词：黄芪颗粒 新生儿败血症 炎症因子 

分 类 号：R722.131[医药卫生—儿科]