六磨汤联合尿毒清颗粒改善腹膜透析患者便秘的疗效分析  

Effectiveness Analysis of Liumo Decoction and Niaoduqing Granules in Improving Constipation of Peritoneal Dialysis Patients

作　　者：程妩铭 江罗佳[1] 张丰萍 孙丽霞 唐瑞 夏琴琴 许慧慧[1] 冯晓然[1] HENG Wuming;JIANG Luojia;ZHANG Fengping;SUN Lixia;TANG Rui;XIA Qinqin;XU Huihui;FENG Xiaoran(Jiujiang NO.1 People's Hospital,Jiangxi Province,Jiujiang 332000,China;不详)

机构地区：[1]江西省九江市第一人民医院,江西九江332000

出　　处：《中国医学创新》2023年第33期84-88,共5页Medical Innovation of China

基　　金：2022年度江西省中医药管理局科技计划项目(2022B278)。

摘　　要：目的:研究六磨汤+尿毒清颗粒运用于腹膜透析患者便秘中的价值。方法:选择2022年6月1日—2023年5月31日九江市第一人民医院收住的腹膜透析便秘患者60例,通过随机数字表法进行分组,各30例,试验组使用六磨汤+尿毒清颗粒,对照组选择常规治疗,两组均持续治疗4周。对比两组总有效率、症状积分、排便难度(CCS)、粪便性状(Bristol)评分、炎症指标、生化指标及不良事件发生率。结果:试验组总有效率为90.00%,高于对照组的66.67%(P<0.05)。服药前两组症状积分、CCS评分、Bristol评分、炎症指标、生化指标差异均无统计学意义(P>0.05),服药后试验组排便困难、腹胀、肛门下坠、排便频率、粪便性状积分、CCS评分、白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、全段甲状旁腺激素(iPTH)、血磷(P)均低于对照组,但血红蛋白(Hb)、血钙(Ca)、白蛋白(Alb)、Bristol评分均高于对照组(P<0.05)。试验组不良事件发生率为6.67%,低于对照组的30.00%(P<0.05)。结论:六磨汤+尿毒清颗粒改善腹膜透析患者便秘的效果更为理想,能够快速减轻相关症状,降低炎症反应,不良事件少,安全性高。Objective:To study the clinical value of Liumo Decoction and Niaoduqing Granules on the constipation of peritoneal dialysis patients.Method:A total of 60 peritoneal dialysis patients with constipation admitted to Jiujiang NO.1 People's Hospital from June 1st,2022 to May 31st,2023 were selected.They were divided into two groups by random number table method,30 cases in each group.Liumo Decoction and Niaoduqing Granules were applied in the experimental group;the routine therapy was applied in the control group.Both groups were treated for 4 weeks.The total effective rate,clinical symptom scores,chronic constipation severity(CCS),stool quality(Bristol score),inflammatory factors,biochemical indicators and adverse reactions were compared.Result:The total effective rate in the experimental group(90.00%)was significantly higher than that(66.67%)of the control group(P<0.05).Before medication,there were no significant differences in the clinical symptoms,CCS and Bristol scores,inflammatory factors and biochemical indicators(P>0.05);after medication,the difficult defecation,abdominal distension,anal straining,defecation frequency,fecal traits and CCS scores,interleukin-6(IL-6),hypersensitivity C reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α),intact parathyroid hormone(iPTH),serum phosphorus(P)in the experimental group were lower than those in the control group;but hemoglobin(Hb),calcium(Ca)and albumin(Alb)levels and Bristol scores were higher than those of control group(P<0.05).The adverse event rate in the experimental group(6.67%)was lower than 30.00%of the control group(P<0.05).Conclusion:The effect of Liumo Decoction and Niaoduqing Granules in improving constipation of peritoneal dialysis patients is more ideal,which can quickly reduce the related symptoms,reduce the inflammatory reaction,with fewer adverse events and high safety.

关 键 词：便秘 六磨汤 腹膜透析 尿毒清颗粒 

分 类 号：R692.5[医药卫生—泌尿科学] R574.62[医药卫生—外科学]