三黄煎剂改善三阴乳腺癌患者气虚症状的研究  

Sanhuang decoction in improving Qi deficiency of patients with triple negative breast cancer

作　　者：许岩磊 解蓉婷[3] 姚昶 王聪 冯鸣[1,2] 李振 XU Yanlei;XIE Rongting;YAO Chang;WANG Cong;FENG Ming;LI Zhen(Department of Breast Surgery,Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing,Jiangsu 210029,China;不详)

机构地区：[1]南京中医药大学附属医院乳腺外科,江苏南京210029 [2]江苏省中医院,江苏南京210029 [3]南京市江宁区中医院,江苏南京211100

出　　处：《中国临床研究》2023年第11期1668-1672,共5页Chinese Journal of Clinical Research

基　　金：国家自然科学基金(81804103);江苏省中医院高峰学术人才项目(k2021yrc37)。

摘　　要：目的观察三黄煎剂对三阴乳腺癌患者气虚症状、生活质量的影响,并探讨其机制。方法将2018年1月至12月江苏省中医院乳腺外科门诊就诊的30例三阴乳腺癌患者随机分为两组,治疗组和对照组各15例,治疗组在对照组治疗的基础上加服三黄煎剂,3个月为1个疗程,治疗2个疗程。治疗前、治疗后3个月、治疗后6个月评估患者气虚症状、免疫指标[CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、白细胞介素(IL)-2、干扰素(IFN)-γ]水平及安全性指标。结果治疗后6个月,治疗组患者气短、神疲、乏力、自汗、懒言症状均改善,免疫指标IL-2、IFN-γ水平改善,与对照组比较差异有统计学意义(P<0.05);CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)虽均有所改善,但与对照组相比差异无统计学意义(P>0.05)。两组患者治疗前后均未出现不良反应。结论三黄煎剂能够显著改善三阴性乳腺癌患者的气虚症状,其机制可能与三黄煎剂提高患者免疫水平有关。Objective To observe the effect of Sanhuang decoction on the symptoms of Qi deficiency and quality of life in patients with triple negative breast cancer(TNBC)and explore its mechanism.Methods From January to December 2018,30 patients with TNBC in the Breast Surgery of Jiangsu Provincial Hospital of Chinese Medicine were randomly divided into treatment group(n=15)and control group(n=15).The patients in treatment group received Sanhuang decoction on the basis of basic treatment,with two courses of treatment(3 months was a course).The patient's symptoms of Qi deficiency,immune indicators(CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),IL-2,IFN-γ)levels before treatment and 3 and 6 months after treatment,and safety indicators were compared.Results After 6 months of treatment,the symptoms of breath shortness,fatigued spirit,lack of strength,spontaneous sweating,and lazy speech in the treatment group were improved,and the levels of immune indicators IL-2 and IFN-γwere improved,and there were statistically significant differences compared to the control group(P<0.05).Although there were improvements in CD3^(+),CD4^(+),CD8^(+),and CD4^(+)/CD8^(+),but with no statistically significant difference compared to the control group(P>0.05).Both groups of patients showed no adverse reactions before and after treatment.Conclusion Sanhuang decoction can significantly improve the symptoms of Qi deficiency of patients with TNBC.The mechanism may be related to the improvement of immune level of patients with Sanhuang decoction.

关 键 词：三黄煎剂 乳腺癌 三阴性 气虚症状 免疫功能 

分 类 号：R737.9[医药卫生—肿瘤] R273[医药卫生—临床医学]