鼻腔给药在神经系统疾病治疗中的研究进展  

Research Progress of Intranasal Drug Delivery System for Treatment of Central Nervous System Diseases

作　　者：杨丽 侯曙光 周璇 YANG Li;HOU Shuguang;ZHOU Xuan(Hainan Meikangda Pharmaceutical Co.,Ltd.,Chengdu 610093,China;Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China;Chengdu Dirui Pharmaceutical Technology Co.,Ltd.,Chengdu 610093,China)

机构地区：[1]海南美康达药业有限公司,成都610093 [2]成都中医药大学,成都611137 [3]成都砥睿医药科技有限公司,成都610093

出　　处：《中国现代应用药学》2023年第20期2865-2871,共7页Chinese Journal of Modern Applied Pharmacy

摘　　要：鼻腔给药可以避开血脑屏障、胃肠道降解和肝脏首过效应,经过嗅神经通路直接到达脑部,因而被用于多种神经系统疾病的治疗。本文综述了鼻腔解剖、鼻腔给药治疗中枢神经系统疾病的转运通路、作用机制、临床应用、面临挑战和新技术等方面的研究进展。Intranasal drug administration can avoid the blood-brain barrier,gastrointestinal degradation and liver first-pass effect,and may directly deliver drugs to the brain through the olfactory nerve pathway,so it is being used for the treatment of various neurological diseases.This article reviewed the research progress of intranasal drug delivery in terms of nasal anatomy,transport pathways of intranasal drug delivery for central nervous system diseases,mechanisms of action,clinical application,challenges and novel technologies.

关 键 词：鼻腔给药 中枢神经系统 血脑屏障 递送系统 

分 类 号：R969.3[医药卫生—药理学]