桑枝总生物碱与阿卡波糖在痰浊瘀阻型餐后高血糖患者中的临床疗效比较  

Comparison of Clinical Efficacy of Sangzhi Alkaloids and Acarbose in Patients with Postprandial Hyperglycemia Caused by Phlegm Turbidity and Blood Stasis Obstruction Syndrome

作　　者：方朝晖[1] 王安 高洁 代本玲 许成群 韩进军 李锐[7] 梅阳生 李双喜 FANG Zhaohui;WANG An;GAO Jie;DAI Benling;XU Chengqun;HAN Jinjun;LI Rui;MEI Yangsheng;LI Shuangxi(The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Anhui Hefei 230031,China;Anqing Petrochemical Hospital,Anhui Anqing 246000,China;Fengyang Hospital of Traditional Chinese Medicine,Anhui Fengyang 233100,China;Changfeng Hospital of Traditional ChineseMedicine,Anhui Changfeng 231100,China;Huaibei Hospital of Traditional Chinese Medicine,Anhui Huaibei 235000,China;Jieshou City Traditional Chinese Medicine Hospital,Anhui Jieshou 236500,China;Suzhou Hospital of Traditional Chinese Medicine,Anhui Suzhou 234000,China;Tongcheng Hospital of Traditional ChineseMedicine,Anhui Tongcheng 231400,China;Wangjiang Hospital of Traditional Chinese M edicine,Anhui Wangjiang 246200,China)

机构地区：[1]安徽中医药大学第一附属医院,安徽合肥230031 [2]安徽省安庆石化医院,安徽安庆246000 [3]安徽省凤阳县中医院,安徽凤阳233100 [4]安徽省长丰县中医院,安徽长丰231100 [5]安徽省淮北市中医院,安徽淮北235000 [6]安徽省界首市中医院,安徽界首236500 [7]安徽省宿州市中医院,安徽宿州234000 [8]安徽省桐城市中医院,安徽桐城231400 [9]安徽省望江县中医院,安徽望江246200

出　　处：《中医药临床杂志》2023年第11期2208-2212,共5页Clinical Journal of Traditional Chinese Medicine

基　　金：国家中医药传承创新中心(2023-21);安徽省高等学校省级质量工程项目(2021jyxm0834);安徽高校协同创新项目(GXXT-2020-025);糖脂代谢病教育部重点实验室开放基金(GYDKFXM01);2型糖尿病中医药循证能力提升项目(2023-24);安徽省重大疑难疾病糖尿病中西医协同攻关项目(2021zdynjb06);安徽省医疗卫生重点专科中医内分泌建设项目(2021-273)。

摘　　要：目的:比较桑枝总生物碱(SZ-A)和阿卡波糖(AC)在痰浊瘀阻型餐后高血糖患者中的临床效果及中医证候改善差异性。方法:将90例痰浊瘀阻型2型糖尿病患者。患者被随机分为对照组(接受AC治疗)和治疗组(接受SZ-A治疗),对照组30例,治疗组60例。研究期为12周,期间定期对患者进行随访,并观察药物的临床指标。结果:治疗后,治疗组的中医临床疗效为75%,显著优于对照组的40%。在血液指标方面,两组患者治疗后的血糖、胰岛素、胆固醇等指标均有明显改善。尤其在甘油三酯(TG)的改善程度上,SZ-A组明显优于AC组。此外,两组患者的体重指数(BMI)在治疗后都有所下降。结论:SZ-A和AC在降低痰浊瘀阻型餐后高血糖患者的血糖水平上具有同等效果,但SZ-A在改善中医证候积分、临床疗效、降低总胆固醇、炎症反应、以及减少胃肠道不良反应方面更优于AC。Objective:To compare the clinical effects and differences in traditional Chinese medicine syndrome improvement of total alkaloids of mulberry branches(SZ-A)and acarbose(AC)in patients with postprandial hyperglycemia of phlegm turbidity and blood stasis type.Methods:90 cases of type 2 diabetes with turbid phlegm and blood stasis were studied.The patients were randomly divided into a control group(receiving AC treatment)and a treatment group(receiving SZ-A treatment),with 30 cases in the control group and 60 cases in the treatment group.The research period is 12 weeks,during which patients are regularly followed up and clinical indicators of the medication are observed.Result:After treatment,the clinical efficacy of traditional Chinese medicine in the treatment group was 75%,significantly better than the control group’s 40%.In terms of blood indicators,both groups of patients showed significant improvement in blood glucose,insulin,cholesterol and other indicators after treatment.Especially in terms of the improvement of triglycerides(TG),the SZ-A group was significantly better than the AC group.In addition,the body mass index(BMI)of both groups of patients decreased after treatment.Conclusion:SZ-A and AC have the same effect in reducing blood sugar levels in patients with postprandial hyperglycemia caused by phlegm stagnation.However,SZ-A is superior to AC in improving traditional Chinese medicine syndrome scores,clinical efficacy,reducing total cholesterol,inflammatory reactions,and reducing gastrointestinal adverse reactions.

关 键 词：2型糖尿病 餐后高血糖 痰浊瘀阻 桑枝总生物碱 阿卡波糖 

分 类 号：R587.1[医药卫生—内分泌]