基于数据挖掘探讨中药复方治疗高血压早期肾损害的用药规律  

Medication Rules of Traditional Chinese Medicine Compounds in Treating Early Hypertensive Nephrosclerosis Based on Data Mining

作　　者：赵金月 韩宇博[2] 隋艳波[2] 邹国良[2] 李红岩[1] 刘莉[2] ZHAO Jinyue;HAN Yubo;SUI Yanbo;ZOU Guoliang;LI Hongyan;LIU Li(Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,China)

机构地区：[1]黑龙江中医药大学,哈尔滨150040 [2]黑龙江中医药大学附属第一医院,哈尔滨150040

出　　处：《中西医结合心脑血管病杂志》2023年第23期4272-4278,共7页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家自然科学基金项目(No.82074346);黑龙江省博士后经费项目(No.LBH-Z18253);黑龙江中医药大学校科研基金项目(No.2019TD01,2019BS02)。

摘　　要：目的:利用数据挖掘技术对治疗高血压早期肾损害(EHN)的中药复方进行分析,以探讨EHN的用药规律,优化EHN的诊疗方案。方法:检索中国知网、万方、维普、中国生物医学数据库中主治疾病为EHN的中药方剂,进行用药频次、性味归经、药物用量、相关性、关联规则及聚类分析,探究EHN治疗的组方规律。结果:共纳入文献79篇,处方82首,涉及中药128味,用药频次867次。频数≥10次的中药共28味,排名前5位的中药分别为丹参、山茱萸、茯苓、山药、牛膝。四气以温、寒居多,五味以甘、苦、辛为主,归经多入肝、肾、脾经。设置关联规则支持度≥25%,置信度≥90%,提升度>1,获得17种常用药物组合。聚类分析获得3组适用于不同证型的新处方。结论:中医辨治EHN以滋阴潜阳、活血通络为主,兼以清泻虚热、化痰祛湿。通过数据挖掘技术,为临床遣方用药及新方新药研发提供参考。Objective:Data mining technology was used to analyze the traditional Chinese medicine(TCM)compounds for treating early hypertensive nephrosclerosis(EHN).Methods:TCM compounds with EHN as the main disease were searched from China National Knowledge Infrastructure(CNKI),Wanfang Data,Wipro Chinese Full-text Database of Scientific,and Technological Journals(VIP),and Chinese Biomedical Literature Service System(SinoMed).The drug frequency,property,flavors,attributive channel,drug dosage,correlation,association rules,and cluster analysis were carried out to explore the prescription formation rule of EHN treatment.Results:A total of 79 literatures were included,with 82 prescriptions,involving 128 flavors of TCM,and the frequency of medication was 867 times.There were 28 herbs with frequency≥10 times,and the top 5 herbs were radix salviae,cornus officinalis sieb,poria cocos,rhizoma dioscoreae and achyranthis bidentatae radix.The four Qi were mainly warm and cold,and the five tastes were mainly sweet,bitter and xin,which attributive the liver,kidney,and spleen channels.The association rules were set with support≥25%,confidence≥90%and lift>1 to obtain 17 combinations of commonly used drugs combinations.Three groups of new prescriptions for different syndrome types were obtained by cluster analysis.Conclusion:TCM differentiation and treatment of EHN is mainly based on nourishing Yin and suppressing Yang,promoting blood and clearing collaterals,as well as clearing vacuity and heat,promoting blood circulation for removing obstruction in collaterals,as well as clearing deficiency heat,resolving phlegm and dispelling dampness.Through data mining technology,will provide reference for clinical prescriptions and the development of new prescriptions and medicines.

关 键 词：高血压早期肾损害 数据挖掘 中药 用药规律 

分 类 号：R259[医药卫生—中西医结合]