蛋白质组学在自身免疫病生物标志物研究中的进展和策略  

Advances and strategies of proteomics in autoimmune disease biomarker research

作　　者：李詹 李永哲[1] Li Zhan;Li Yongzhe(Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院、北京协和医学院、北京协和医院检验科,北京100730

出　　处：《中华检验医学杂志》2023年第11期1113-1122,共10页Chinese Journal of Laboratory Medicine

基　　金：国家重点发展计划(2018YFE0207300);北京市科技计划(Z211100002521021);中央高水平医院临床科研业务(2022-PUMCH-B-124)。

摘　　要：自身免疫病是机体免疫自稳状态破坏导致免疫病理损伤和功能障碍的疾病。生物标志物的发现和应用为临床早期诊断、疾病活动度监测及预后和治疗效果评估提供重要价值。蛋白质组学是寻找自身免疫病生物标志物的重要方法,其在该领域已经取得一定进展,随着技术的发展和研究的深入,未来蛋白质组学将发挥更大价值。Autoimmune diseases are a series of diseases that induce the damage and dysfunction of human immune-system due to the destruction of immune homeostasis.The discovery and application of biomarkers provide important value for early clinical diagnosis,disease activity monitoring,improved prognosis and more effect treatment.Proteomics related methods are important strategies to discover biomarkers for autoimmune diseases,and certain progress has been made in the related field.With the development of technology and the deepening of research,proteomics will have a greater value in the future.

关 键 词：自身免疫疾病 诊断 蛋白质组学 生物学标记 

分 类 号：R593.2[医药卫生—内科学]