自身免疫性心肌病相关自身抗体谱研究进展  

Progress in autoantibody profile for autoimmune cardiomyopathy

作　　者：张婧頔 李永哲[1] Zhang Jingdi;Li Yongzhe(Department of Clinical Laboratory,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院、北京协和医学院、北京协和医院检验科,北京100730

出　　处：《中华检验医学杂志》2023年第11期1205-1210,共6页Chinese Journal of Laboratory Medicine

基　　金：国家重点发展计划(2018YFE0207300);中央高水平医院临床科研业务(2022-PUMCH-B-124)。

摘　　要：自身免疫性心肌病是一类由自身免疫介导的异质性心肌疾病,其具体发病机制尚未明确。多种自身抗体已在自身免疫性心肌病患者的血清中检出,相关自身抗体谱的研究有助于了解疾病的发病机制,提高疾病筛查和诊断效能、监测疾病进展、评估预后和治疗效果等。本文将总结自身免疫性心肌病中相关自身抗体谱的研究进展及临床应用,以为临床诊治提供参考。The autoimmune cardiomyopathy is a variety of myocardial diseases with significant individual heterogeneity that is mediated by autoimmunity reaction.However,the pathogenesis of the autoimmune cardiomyopathy has not been clearly known.Multiple autoantibodies have been detected in the sera of patients with autoimmune cardiomyopathy,and the studies of related autoantibody profile contributes to understanding the pathogenesis,improving screening and diagnosis,supervising disease progression,estimating prognosis and therapeutic effects.This review will summarize the progress and clinical application of the autoantibody profile in patients with autoimmune cardiomyopathy,providing a reference for clinical practice.

关 键 词：心肌病 自身免疫 自身抗体 自身抗原 

分 类 号：R542.2[医药卫生—心血管疾病] R446.6[医药卫生—内科学]