细胞焦亡分子机制及其调控  

Molecular Mechanism and Regulation of Pyroptosis

作　　者：韦双 高维崧 窦金萍 赵泽鹏 刘兴健[1] 李轶女[1] WEI Shuang;GAO Weisong;DOU Jinping;ZHAO Zepeng;LIU Xingjian;LI Yinyu(Biotechnology Research Institute,Chinese Academy of Agricultural Science,Beijing 100081,China)

机构地区：[1]中国农业科学院生物技术研究所,北京100081

出　　处：《生物技术进展》2023年第6期868-874,共7页Current Biotechnology

基　　金：国家重点研发计划项目(2022YFD13007);国家自然科学基金项目(32072796,32372952,32002236)。

摘　　要：与基因相关的细胞死亡途径统称为细胞程序性死亡,细胞焦亡是一种新近发现的依赖炎性半胱天冬氨酸酶,并且伴随炎症反应的细胞程序性死亡方式。细胞焦亡的生物学特征、发生与调控机制都区别于其他细胞死亡方式。简要概述了细胞焦亡的研究历史,并从非编码RNA、细胞应激、受体蛋白和化学物质4个方面详细介绍了细胞焦亡的影响因素和调控机制,以期明确细胞焦亡在先天免疫中的角色。The gene-related pathway of cell death is summarized as programmed cell death.Pyroptosis is a recently discovered mode of programmed cell death that depends on inflammatory caspases and is accompanied by an inflammatory response.The biological characteristics,occurrence and regulation mechanism of pyroptosis are different from other cell death methods.In this paper,we briefly overviewed the research history of pyroptosis,and deliberately introduced the influence factors and regulatory mechanisms of pyroptosis,including non-coding RNA,cell stress,receptor protein and chemical substances,which maybe contribute to clarify the role of pyroptosis in innate immunity.

关 键 词：细胞焦亡 炎症小体 炎性半胱天冬氨酸酶 成孔效应蛋白D 

分 类 号：Q291[生物学—细胞生物学] R392.1[医药卫生—免疫学]