细胞膜色谱技术在多肽类成分筛选的研究进展  

Research progress of cell membrane chromatography in screeningactive components of polypeptides

作　　者：孙铁锋[1] 王平[1,2] 丁相龙 丁立钧 姜其宝 王金国 SUN Tiefeng;WANG Ping;DING Xianglong;DING Lijun;JIANG Qibao;WANG Jinguo(Shandong Academic of Chinese Medicine,Jinan 250014,China;State Key Laboratory of Precision Testing Technology and Instruments,Tianjin University,Tianjin 300072,China;Huangdao District Second Hospital of Traditional Chinese Medicine,Qingdao 266400,China;Rizhao Traditional Chinese Medicine Hospital,Rizhao 276800,China;Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东省中医药研究院,山东济南250014 [2]天津大学精密测试技术及仪器国家重点实验室,天津300072 [3]青岛市黄岛区第二中医医院,山东青岛266400 [4]日照市中医医院,山东日照276800 [5]山东中医药大学,山东济南250355

出　　处：《药学研究》2023年第11期926-931,936,共7页Journal of Pharmaceutical Research

基　　金：山东省中医药科技项目(No.2020Q023);山东省自然科学基金(No.ZR2020MH386);国家重点研发计划政府间国际科技创新合作项目(No.2019YFE0117800);中央引导地方科技发展专项基金(No.YDZX2021117);山东省重点研发计划(科技示范工程)(No.2021SFGC1205)。

摘　　要：近年来,随着色谱技术的不断发展,细胞膜色谱在多肽类活性物质的研究中得到了广泛的应用。本文在总结国内外相关文献的基础上,介绍了细胞膜色谱技术的原理和特点、细胞膜色谱技术的分类以及细胞色谱技术在多肽类活性成分的研究进展。总结并提出了细胞膜色谱检测多肽的优点、目前存在的问题,展望了前景。In recent years,with the continuous development of chromatography technology,cell membrane chromatography has been widely used in study of polypeptide active substances.On basis of summarizing the relevant literature at home and abroad,this paper introduced the principle and characteristics of cell membrane chromatography,the classification of cell membrane chromatography and the research progress of cell chromatography in polypeptide active components.The advantages and existing problems of polypeptide detection by cell membrane chromatography were summarized and put forward,and the prospect was prospected.

关 键 词：细胞膜色谱 多肽类成分 筛选 

分 类 号：R965.1[医药卫生—药理学]