基于数据挖掘探讨补骨脂致肝损伤临床症候和防治  

Clinical symptoms and treatment of Psoralen induced liver injury based on data mining

作　　者：王静宜 吕明月 殷佳[2] 王信[2] 刘慧 傅春升[2] WANG Jingyi;LYU Mingyue;YIN Jia;WANG Xin;LIU Hui;FU Chunsheng(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东中医药大学附属医院,山东济南250014

出　　处：《药学研究》2023年第11期943-948,共6页Journal of Pharmaceutical Research

基　　金：国家自然科学基金资助项目(No.82104506);山东中医药科技发展计划项目(No.2019-0079)。

摘　　要：目的 通过对服用补骨脂及其制剂导致肝损伤的病例进行回顾性分析,探讨补骨脂及其制剂导致肝损伤特点和规律。方法 收集2016年1月—2021年1月服用补骨脂及补骨脂制剂患者共计37 419例,筛选诊断为补骨脂及其制剂致肝损伤的住院病例,剔除住院时间低于两周,数据严重不全患者。采用SPSS 26.0对入选病例的年龄、性别、用药目的、临床表现、药物治疗转归情况进行统计分析;采用Cytoscape v3.9.1对入选病例的中药配伍情况进行数据挖掘分析。结果 共收集到353例补骨脂及其制剂致肝损伤的病例,使用药物为中药盐补骨脂298例,占比为84.41%;使用含补骨脂制剂共55人,占比为15.58%。中药配伍中与盐补骨脂关联度较高的前6位是黄芪、甘草、当归、生地黄、制五味子、盐小茴香。使用频率较高的前3位保肝中药是黄芪、甘草、制五味子。结论 患者服用补骨脂期间应按规定的剂量,临床上应加强对中老年患者用药时的肝功能监测,注重补骨脂的质量监控,从中药配伍炮制方面寻找更有效的减毒方法。Objective To conduct a retrospective analysis of cases of liver injury caused by taking Psoralen and its preparations,to explore the characteristics and laws of liver injury caused by Psoralen and its preparations.Methods All cases of patients taking Psoralen and Psoralen preparations were collected,totaling 37419 cases,and hospitalized cases diagnosed with liver injury caused by Psoralen and its preparations were screened,and patients with hospitalization time less than two weeks and severely incomplete data were excluded,and SPSS 26.0 was used to statistically analyze the age,gender,purpose of medication,clinical manifestations,and medication regression of the selected cases;Cytoscape v3.9.1 was used to analyze the data mining of the Chinese herbal medicine combinations of the selected cases.Results A total of 353 cases of liver injury caused by Psoralen and its preparations were collected.The drug used was Chinese herbal salt Psoralen in 298 cases,accounting for 84.41%;A total of 55 patients(15.58%)used Psoralen-containing preparations.The top six Chinese herbal preparations with high association with salt Psoralen reinforcing fat were Astragalus membranaceus,Glycyrrhiza glabra,Radix Angelicae Sinensis,Radix et Rhizoma Dioscoreae,Fructus Schisandrae,and salt Cumin.The top three liver-protecting herbs with high frequency of use were Astragalus,Glycyrrhiza and Schisandra.Conclusion Patients should take psoralen during the prescribed dose,clinically should strengthen the monitoring of liver function in middle-aged and elderly patients when taking drugs,pay attention to the quality monitoring of Psoralen,and find more effective attenuation methods from the preparation of traditional Chinese medicine.

关 键 词：药物性肝损伤 盐补骨脂 补骨脂 数据挖掘 

分 类 号：R969.3[医药卫生—药理学]