人源溶菌酶结构与功能的研究进展  

Structure and function of human-derived lysozyme:a review

作　　者：刘汝薇 孟庆勇[2] 戴蕴平[2] 张雅丽[1] LIU Ruwei;MENG Qingyong;DAI Yunping;ZHANG Yali(College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China;College of Biological Sciences,China Agricultural University,Beijing 100193,China)

机构地区：[1]中国农业大学食品科学与营养工程学院,北京100083 [2]中国农业大学生物学院,北京100193

出　　处：《生物工程学报》2023年第11期4482-4496,共15页Chinese Journal of Biotechnology

基　　金：国家现代农业产业技术体系(CARS36)。

摘　　要：人溶菌酶是一类人体内天然存在的能够溶解细菌细胞壁的碱性蛋白的总称。其作用特征是能够裂解肽聚糖中的N-乙酰氨基葡萄糖与N-乙酰氨基甲酸之间的β-(1,4)-糖苷键。人溶菌酶具有抗菌、抗炎、抗病毒和增强免疫力等多种特性,因此在国内外市场上应用广泛。本文就人溶菌酶的结构特点、表达部位、功能表达以及应用情况进行综述。Human-derived lysozyme is a general term for a group of naturally occurring alkaline proteins in the human body that are capable of lysing bacterial cell walls.Its action is characterized by its ability to cleave the β-(1,4)-glycosidic bond between N-acetylglucosamine and N-acetylmuramic acid in peptidoglycan.Human-derived lysozyme has a variety of properties such as antibacterial,anti-inflammatory,antiviral and immune enhancing,and is therefore widely used in the domestic and international pharmaceutical markets.This review summarizes the structural features,expression sites,biological functions of human-derived lysozymes and its market applications.

关 键 词：人溶菌酶 结构特点 作用机制 生物功能 

分 类 号：Q814[生物学—生物工程]