瑞替普酶治疗急性ST段抬高型心肌梗死的临床效果  

Clinical Effect of Reteplase in Treatment of Acute ST-Segment Elevation Myocardial Infarction

作　　者：张炎 Zhang Yan(Emergency Department,Juancheng County People's Hospital of Heze City,Heze 274600,Shandong Province,China)

机构地区：[1]菏泽市鄄城县人民医院急诊科,山东菏泽274600

出　　处：《中国社区医师》2023年第31期39-41,共3页Chinese Community Doctors

摘　　要：目的:分析瑞替普酶治疗急性ST段抬高型心肌梗死的临床效果。方法:选取2020年2月—2022年2月菏泽市鄄城县人民医院收治的80例急性ST段抬高型心肌梗死患者作为研究对象,随机分为观察组和对照组,各40例。观察组采用瑞替普酶治疗,对照组采用尿激酶治疗。比较两组治疗效果。结果:溶栓后30 min、1 h、2 h,观察组冠状动脉再通率均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组左室射血分数、组织型纤溶酶原激活物水平高于治疗前,且观察组高于对照组,两组左室舒张末期内径、脑钠肽、溶酶原激活物抑制剂、纤溶酶原水平低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组出血总发生率低于对照组,差异有统计学意义(P=0.043)。两组心血管事件总发生率比较,差异无统计学意义(P>0.05)。结论:瑞替普酶治疗急性ST段抬高型心肌梗死的临床效果显著,可提升冠状动脉再通率,改善患者心功能和纤溶指标,降低出血发生率。Objective:To analyze the clinical effect of reteplase in the treatment of acute ST-segment elevation myocardial infarction.Methods:A total of 80 patients with acute ST-segment elevation myocardial infarction admitted to Juancheng County People´s Hospital of Heze City from February 2020 to February 2022 were selected as the study subjects.They were randomly divided into observation group and control group,with 40 cases in each group.The observation group received reteplase treatment,while the control group received urokinase treatment.The treatment effects were compared between two groups.Results:At 30 min,1 h and 2 h after thrombolysis,the coronary artery recanalization rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of left ventricular ejection fraction and tissue-type plasminogen activator in the two groups were higher than those before treatment,and the levels in the observation group were higher than those in the control group,while the levels of left ventricular end-diastolic diameter,brain natriuretic peptide,plasminogen activator inhibitor and plasminogen in the two groups were lower than those before treatment,and the levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).The total incidence of bleeding in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.043).There was no significant difference in the total incidence of cardiovascular events between the two groups(P>0.05).Conclusion:The clinical effect of reteplase in the treatment of acute ST-segment elevation myocardial infarction is significant.It can better increase the coronary artery recanalization rate,improve the cardiac function and fibrinolytic indicators of patients,and reduce the incidence of bleeding.

关 键 词：急性ST段抬高型心肌梗死 瑞替普酶 尿激酶 冠状动脉再通 心功能 

分 类 号：R542.22[医药卫生—心血管疾病]