酮体代谢在心脏中的病理生理作用及相关治疗进展  

Ketone Metabolism in Heart:Pathophysiological Mechanism and Ketone Therapy

作　　者：王晓群[1] 张瑞岩[1] WANG Xiaoqun;ZHANG Ruiyan(Department of Cardiovascular Medicine,Ruijin Hospital,Shanghai Jiaotong University,Shanghai 200025,China)

机构地区：[1]上海交通大学附属瑞金医院心内科,上海200025

出　　处：《心血管病学进展》2023年第11期973-977,共5页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81870179,82170423)。

摘　　要：酮体在人体器官的能量供应中发挥着重要作用。由于心脏具有快速改变底物利用的代谢灵活性,在某些生理或病理状态下,心脏可适应性地增加酮体的摄取和利用以持续供能。此外,酮体还具有抑制氧化应激、减轻炎症、促进血管内皮细胞增殖和改善心脏重构等多种心血管保护作用。因此,适度升高血循环酮体水平可能具备治疗心脏疾病的临床应用前景。尤其是慢性、长期的升酮方式,可能为心力衰竭等心血管疾病患者提供临床获益。Ketone bodies are endogenously synthetized metabolites that become significant contributors to energy metabolism in human organs.The heart is metabolically flexible and can readily shift between different energy substrates to maintain energy production.The consumption and utilization of myocardial ketone bodies is increased during pathological and physiological conditions.In addition,it was found that ketone bodies play multiple protective roles in cardiovascular system,such as inhibiting oxidative stress,alleviating inflammation,promoting vascular endothelial cell proliferation and improving cardiac remodeling.Therefore,there is potential clinical application prospect for increasing blood ketone body levels moderately in treatment of heart diseases.Especially chronic and long-term elevation of blood ketone body level may provide clinical benefits for patients with cardiovascular diseases such as heart failure.

关 键 词：酮体 代谢 心脏 治疗 

分 类 号：R54[医药卫生—心血管疾病]