肌球蛋白磷酸化靶向亚基家族与心血管疾病  

Myosin Phosphatase Targeting Subunit Family and Cardiovascular Disease

作　　者：赵文巧 朱柏俊 刘宇峰 曹明欣 邓凯 吴心欣 吴华英 ZHAO Wenqiao;ZHU Bojun;LIU Yufeng;CAO Mingxin;DENG Kai;WU Xinxin;WU Huaying(Hunan Normal University School of Medicine,Changsha 410013,Hunan,China)

机构地区：[1]湖南师范大学医学院,湖南长沙410013

出　　处：《心血管病学进展》2023年第11期991-995,共5页Advances in Cardiovascular Diseases

基　　金：湖南省自然科学基金青年项目(2022JJ40287);湖南省教育厅优秀青年项目(21B0081);湖南省中医药管理局资助项目(D2022027);长沙市自然科学基金资助项目(kq2202255);湖南师范大学大学生创新创业训练计划校级项目(2022115)。

摘　　要：肌球蛋白磷酸化靶向亚基(MYPT)家族包含5个成员,MYPT可通过其自身磷酸化影响肌球蛋白轻链磷酸酶(MLCP)活性与细胞功能,调控Rho/ROCK通路和NO/cGMP/PKG通路,从而在心血管疾病的发生发展中发挥重要作用。现就MYPT家族成员的结构、与细胞功能及信号通路的关系及其在心血管疾病中的作用机制进行综述,为心血管疾病的研究和治疗提供理论基础。Myosin phosphatase targeting subunit(MYPT)family includes five members.They can influence the activity of myosin light chain phosphatase(MLCP)and cell function,regulating Rho/ROCK pathway and NO/cGMP/PKG pathway through their own phosphorylation,thus playing an important role in the occurrence and development of cardiovascular disease.This article reviews the structure of MYPT family members,their relationship with cell function and signaling pathways,and their mechanism of action in cardiovascular disease,so as to provide a theoretical basis for the research and treatment of cardiovascular disease.

关 键 词：肌球蛋白磷酸化靶向亚基 心血管疾病 Rho/ROCK通路 NO/cGMP/PKG通路 

分 类 号：R54[医药卫生—心血管疾病]