左心疾病相关性肺动脉高压临床研究进展  

Clinical Research Progress of Pulmonary Hypertension Associated with Left Heart Disease

作　　者：王单 陈玉成[1] WANG Dan;CHEN Yucheng(Department of Cardiology,West China Hospital,Sichuan University,Chengdu 610041,Sichuan,China;Department of Cardiology,West China(Airport)Hospital,Sichuan University,Chengdu 610200,Sichuan,China)

机构地区：[1]四川大学华西医院心内科,四川成都610041 [2]四川大学华西空港医院心内科,四川成都610200

出　　处：《心血管病学进展》2023年第11期996-1000,1009,共6页Advances in Cardiovascular Diseases

基　　金：四川大学华西医院1·3·5项目高端人才支持计划(ZYGD22013)。

摘　　要：肺动脉高压是一大类进展性、致残率和致死率极高的疾病。左心疾病相关性肺动脉高压最为常见,其病情更重、预后更差、病死率更高,严重影响患者生活质量。目前该类肺动脉高压的流行病学数据不清楚、临床诊断标准不统一、病理生理机制不甚明确、分类方法存在争议、靶向药物治疗缺乏证据,国内外相关研究和治疗十分有限。现概述左心疾病相关性肺动脉高压的定义及分类、流行病学、病因及发病机制、病理生理机制,并详细阐述其诊断及特异性治疗的临床研究进展。Pulmonary hypertension is a major progressive,highly disabling and fatal disease.Pulmonary hypertension associated with left heart disease is the most common,with a more severe condition,poorer prognosis and higher mortality rate,seriously affecting the quality of life of patients.At present,the epidemiological data of this type of pulmonary hypertension is unclear,clinical diagnostic standards are not unified,pathological and physiological mechanisms are not clear,classification methods are controversial,and there is a lack of evidence for targeted drug therapy.The research and treatment at home and abroad are very limited.This paper reviews the definition,epidemiology,etiology,pathogenesis and pathophysiology of pulmonary hypertension associated with left heart disease,and elaborate the clinical research progress in its diagnosis and specific treatment.

关 键 词：肺动脉高压 左心疾病 诊断 治疗 

分 类 号：R544.1[医药卫生—心血管疾病]