布鲁菌感染性腹主动脉瘤腔内治疗前后细胞因子的表达情况  

Expression of cytokines in abdominal aortic aneurysms infected by Brucella before and after intracavitary therapy

作　　者：黄伯儒 高占峰[1] Huang Boru;Gao Zhanfeng(Department of Vascular Surgery,the Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,Inner Mongolia,China)

机构地区：[1]内蒙古医科大学附属医院血管外科,内蒙古呼和浩特010050

出　　处：《血管与腔内血管外科杂志》2023年第10期1162-1166,共5页Journal of Vascular and Endovascular Surgery

基　　金：2022年自治区卫生健康科技计划项目(202202162);内蒙古医科大学面上项目(YKD2021MS007)。

摘　　要：目的 探讨布鲁菌感染性腹主动脉瘤(IAAA)腔内治疗前后细胞因子的表达情况。方法 收集2015年11月至2022年11月内蒙古医科大学附属医院收治的16例布鲁菌IAAA患者的临床资料作为观察组,同期收集16例AAA患者的临床资料作为对照组,两组患者均进行腔内修复术(EVAR),观察组患者在此基础上进行抗感染治疗,比较两组患者辅助性T细胞(Th)1、Th2、红细胞沉降率(ESR)、C反应蛋白(CRP)水平、白细胞(WBC)水平。结果 观察组患者偏心性囊状动脉瘤比例高于对照组患者,差异有统计学意义(P﹤0.05)。治疗前,观察组患者白细胞介素(IL)-2、IL-4、IL-6、IL-10、γ干扰素(IFN-γ)水平均高于对照组患者,差异均有统计学意义(P﹤0.05)。治疗后,观察组患者IL-2、IL-4、IL-6、IL-10、IFN-γ水平均低于本组治疗前,肿瘤坏死因子-α(TNF-α)水平高于本组治疗前;观察组患者IL-2、IL-4、IL-6、IL-10、IFN-γ、TNF-α水平均高于对照组患者,差异均有统计学意义(P﹤0.05)。治疗前,观察组患者CRP、ESR均高于对照组患者,差异均有统计学意义(P﹤0.05)。治疗后,观察组患者CRP、ESR均低于本组治疗前,且观察组患者CRP水平低于对照组患者,差异均有统计学意义(P﹤0.05)。结论 布鲁菌IAAA患者EVAR治疗前后采用有效的连续抗感染治疗措施,及时监测布鲁菌IAAA患者炎性细胞因子水平的变化情况,可为临床治疗提供参考。Objective To investigate the expression of cytokines in Brucella infected abdominal aortic aneurysm(IAAA)before and after intracavitary therapy.Method The clinical data of 16 patients with Brucella IAAA admitted to the Affiliated Hospital of Inner Mongolia Medical University from November 2015 to November 2022 were collected as the observation group,and the clinical data of 16 patients with AAA during the same period were collected as the control group.Endovascular aneurysm repair(EVAR)was performed in both groups,and the patients in the observation group received anti-infective treatment on the basis of EVAR.The levels of helper T cell(Th)1,Th2,erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)and white blood cell(WBC)were compared between the two groups.Result The proportion of eccentric cystic aneurysm in observation group was higher than that in control group,the difference was statistically significant(P<0.05).Before treatment,the levels of interleukin(IL)-2,IL-4,IL-6,IL-10,and interferon-γ (IFN-γ) in observation group were higher than those in control group, the differences were statistically significant (P<0.05). After treatment, the levels of IL-2, IL-4, IL-6, IL-10 and IFN-γ in observation group were lower than before treatment, and the levels of tumor necrosis factor-α (TNF-α) were higher than before treatment;the levels of IL-2, IL- 4, IL-6, IL-10, IFN-γ and TNF-α in observation group were higher than those in control group, the differences were statistically significant (P<0.05). Before treatment, CRP and ESR in observation group were higher than those in control group, the differences were statistically significant (P<0.05). After treatment, CRP and ESR in observation group were lower than their before treatment, CRP level in observation group was lower than that of control group, the differences were statistically significant (P<0.05). Conclusion The use of effective continuous anti-infective treatment in Brucella IAAA patients with EVAR before and after surgery, and timely monitorin

关 键 词：布鲁菌 感染性腹主动脉瘤 细胞因子 腔内治疗 

分 类 号：R543[医药卫生—心血管疾病]