儿童狼疮性肾炎分型及治疗策略  

Renal pathologic classification and treatment strategy in children with lupus nephritis

作　　者：高春林 GAO Chunlin(Department of Pediatrics,Jinling Hospital,Department of Pediatrics,Jinling Hospital,Medical School of Nanjing University,Department of Pediatrics,Jinling Hospital,Nanjing Medical University,Department of Pediatrics,Jinling Hospital,The First School of Clinical Medicine,Southern Medical University,Nanjing 210002,Jiangsu,China)

机构地区：[1]东部战区总医院儿科、南京大学医学院附属金陵医院(东部战区总医院)儿科、南京医科大学附属金陵医院儿科、南方医科大学第一临床医学院附属金陵医院儿科,江苏南京210002

出　　处：《临床儿科杂志》2023年第12期887-894,共8页Journal of Clinical Pediatrics

基　　金：东部战区总医院临床研究专项(No.22LCYY-XH9)。

摘　　要：儿童狼疮性肾炎(LN)是儿童最常见的肾小球疾病,起病及病情进展均较成人严重,预后较其他肾小球疾病差,影响终生,病因未完全阐明。文章根据最新的国际指南,对儿童LN的病理分型及其相应治疗进行阐述。LN诊断根据2019年EULAR/ACR系统性红斑狼疮分类标准,肾活检病理是目前的诊断的重要手段,增殖型和非增殖型LN治疗分为初始及维持治疗,参照成人指南推荐,合理和积极的治疗对于诱导疾病缓解和避免复发、改善预后非常重要。Lupus nephritis(LN)is the most common glomerular disease in children,with a more severe onset and progression compared to adults.The prognosis of LN in children is worse than other glomerular diseases and has lifelong effects,although the etiology remains unclear.This article provides an overview of the current diagnosis and treatment status of LN in children,along with a brief description of the treatment for each type of LN based on the latest international guidelines.LN was diagnosed according to the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus.Renal biopsy pathology is an important diagnostic method at present.Treatment for proliferative and non-proliferative LN includes initial therapy and maintenance therapy,following recommendations from adult guidelines.Rational and proactive treatment is crucial for inducing disease remission,preventing relapse,and improving prognosis.

关 键 词：系统性红斑狼疮 狼疮性肾炎 治疗 儿童 

分 类 号：R725.9[医药卫生—儿科]